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Recent items - BMC 中医药

Panax ginseng therapy for chronic obstructive pulmonary disease: a clinical trial protocol and pilot study
14/08/2014 03:44
Background: Panax ginseng (Ren shen) has been used to treat chronic obstructive pulmonary disease (COPD). This article aims to present a study protocol and pilot trial comparing P. ginseng with placebo for treating moderate to very severe COPD. Metho
Bioactive proteins and peptides isolated from Chinese medicines with pharmaceutical potential
19/07/2014 17:12
Some protein pharmaceuticals from Chinese medicine have been developed to treat cardiovascular diseases, genetic diseases, and cancer. Bioactive proteins with various pharmacological properties have been successfully isolated from animals such as Hir
Differential effects of selective frankincense (Ru Xiang) essential oil versus non-selective sandalwood (Tan Xiang) essential oil on cultured bladder cancer cells: a microarray and bioinformatics study
02/07/2014 04:48
Background: Frankincense (Boswellia carterii, known as Ru Xiang in Chinese) and sandalwood (Santalum album, known as Tan Xiang in Chinese) are cancer preventive and therapeutic agents in Chinese medicine. Their biologically active ingredients are usu
Myriad and its implications for patent protection of isolated natural products in the United States
01/07/2014 04:37
Extracts and compounds of natural products have potential as alternatives to current Western medicines. However, these products may not be patentable under the statutory requirements because of their naturally-occurring nature. This article analyzes
Platycodin D from Platycodonis Radix enhances the anti-proliferative effects of doxorubicin on breast cancer MCF-7 and MDA-MB-231 cells
09/06/2014 21:30
Background: It has been demonstrated that platycodin D (PD) exhibits anti-cancer activities. This study aims to investigate the anti-proliferative effects of the combination of PD and doxorubicin (DOX) on human breast cancer cells (MCF-7 and MDA-MB-2
Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study
08/05/2014 15:00
Background: Cordyceps cicadae is a medicinal fungus that is often used for treating cancer. However, the anticancer mechanisms of C. cicadae are largely unknown. This study aims to investigate the anticancer mechanisms of C. cicadae against hepatocel
Isodeoxyelephantopin from Elephantopus scaber (Didancao) induces cell cycle arrest and caspase-3-mediated apoptosis in breast carcinoma T47D cells and lung carcinoma A549 cells
17/04/2014 22:31
Background: Isodeoxyelephantopin (IDOE) isolated from Elephantopus scaber L. (Didancao) is used in Chinese medicine for the treatment of some types of cancer. The anti-cancer mechanism of IDOE remains unclear. This study aims to investigate the antip
Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells
09/04/2014 21:59
Some Chinese herbs are anti-thrombolysis, and anti-inflammatory, improves brain RNA content, promotes brain protein synthesis, enhances dopamine function, regulates brain hormones, and improves microcirculation in central nervous system that might im
Cratoxylum formosum (Jack) Dyer ssp. pruniflorum (Kurz) Gogel: (Hong ya mu) extract induces apoptosis in human hepatocellular carcinoma HepG2 cells through caspase-dependent pathways
07/04/2014 11:05
Background: Cratoxylum formosum (Jack) Dyer ssp. pruniflorum (Kurz) Gogel. (Hong ya mu) (CF) has been used for treatment of fever, cough, and peptic ulcer. Previously, a 50% ethanol-water extract from twigs of CF was shown highly selective in cytotox
Ginsenoside compound K induces apoptosis in nasopharyngeal carcinoma cells via activation of apoptosis-inducing factor
02/04/2014 07:05
Background: Nasopharyngeal carcinoma (NPC) has a high incidence rate in Southern China. Although there are conventional therapies, the side effects and toxicities are not always tolerable for patients. Recently, the tumoricidal effect of ginsenosides
Identification of seven Zingiberaceous species based on comparative anatomy of microscopic characteristics of seeds
08/03/2014 08:44
Background: The fruits and seeds of Alpinia galanga (L.) Willd., Alpinia katsumadai Hayata, Alpinia zerumbet (Pers.) Burtt. & Smith, Amomum kravanh Pierre ex Gagnep., Amomum subulatum Roxb., Amomum tsao-ko Crevost et Lemaire, and Elettaria cardamomum
Problems and prospects of current studies on the microecology of tongue coating
05/03/2014 10:47
Tongue diagnosis in traditional Chinese medicine (TCM) assesses the health by investigation of tongue coating. The science and technology of tongue coating analysis have become a significant issue for modernization of TCM. The relationship between mi
Lignans from the bark of Eucommia ulmoides inhibited Ang II-stimulated extracellular matrix biosynthesis in mesangial cells
14/02/2014 04:58
Background: Tree bark of Eucommia ulmoides Oliv., (commonly well-known as "Du-zhong" in China), has been used to treat hypertension, hypercholesterolemia, hyperglycemia, hepatic fibrosis and renal injury. This study aims to investigate the effects of
Annual acknowledgement of manuscript reviewers
11/02/2014 18:15
Contributing reviewersThe editors of Chinese Medicine would like to thank all our reviewers who have contributed to the journal in Volume 8 (2013).
Computerized tongue image segmentation via the double geo-vector flow
08/02/2014 13:36
Background: Visual inspection for tongue analysis is a diagnostic method in traditional Chinese medicine (TCM). Owing to the variations in tongue features, such as color, texture, coating, and shape, it is difficult to precisely extract the tongue re
Herbal medicines for treating tic disorders: a systematic review of randomised controlled trials
07/02/2014 19:50
Background: It was reported that 64% of tic disorder patients used complementary and alternative medicine. This review aims to evaluate the efficacy of herbal medicines in treating tic disorders. Methods: We searched eight databases including MEDLINE
Anti-infective and cytotoxic properties of Bupleurum marginatum
17/01/2014 16:30
Background: Bupleurum marginatum Wall. ex DC (Apiaceae) is a perennial herb widely used in traditional Chinese and Kampo medicine for the treatment of various infectious diseases. The biological activities of B. marginatum have not been fully investi
Effects of a novel curcumin derivative on insulin synthesis and secretion in streptozotocin-treated rat pancreatic islets in vitro
15/01/2014 00:23
Background: Hyperglycemia induces activation of the c-Jun N-terminal kinase (JNK) pathway, which suppresses insulin gene expression and reduces DNA binding of pancreatic and duodenal homeobox factor (PDX)-1. This study aims to investigate the effects
Quantization and diagnosis of Shanghuo (Heatiness) in Chinese medicine using a diagnostic scoring scheme and salivary biochemical parameters
04/01/2014 08:59
Background: This study aims to establish a diagnostic scoring scheme for Shanghuo (Heatiness) and to evaluate whether Shanghuo is associated with biochemical parameters of salivary lysozyme (LYZ), salivary secreted immunoglobulin (S-IgA), salivary am
Identifying the Zheng in psoriatic patients based on latent class analysis of traditional Chinese medicine symptoms and signs
04/01/2014 03:30
Background: There are approximately five Zhengs reported in psoriatic patients. Systematic data collection and proper analysis for the classification of psoriasis have been lacking. This study aims to cluster the Zhengs in psoriatic patients based on
Phellinus linteus polysaccharide extracts increase the mitochondrial membrane potential and cause apoptotic death of THP-1 monocytes
18/12/2013 04:15
Background: The differentiation resp. death of human monocytic THP-1 cells induced by polysaccharide extracts of the medicinal mushrooms Phellinus linteus, Agaricus bisporus and Agaricus brasiliensis have been studied. This study aims to identify lea
Role of dermatomes in the determination of therapeutic characteristics of channel acupoints: a similarity-based analysis of data compiled from literature
17/12/2013 07:07
Background: Analysis of the relationship between the nervous system anatomy and the therapeutic characteristics of all acupuncture points in the channel network may provide new insights on the physiological mechanisms underlying acupuncture stimulati
Effects of a fixed-intensity of endurance training and pistacia atlantica supplementation on ATP-binding cassette G4 expression
25/11/2013 06:43
Background: Adenosine triphosphate-cassette binding protein (ABC) type G is considered as a part of reverse cholesterol transport (RCT) process in modification and metabolism of plasma and tissue cholesterol. This study aims to evaluate the effect of
Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria
23/11/2013 18:36
Background: Bacterial conversion of ginsenosides is crucial for the health-promoting effects of ginsenosides. Previous studies on the biotransformation of ginsenoside Rb1 (Rb1) by gut bacteria have focused on the ginsenoside Rd (Rd) pathway (Rb1 [rig
Current evidence for the hepatoprotective activities of the medicinal mushroom Antrodia cinnamomea
01/11/2013 19:14
Antrodia cinnamomea (AC) is an endemic mushroom species of Taiwan, and has been demonstrated to possess diverse biological and pharmacological activities, such as anti-hypertension, anti-hyperlipidemia, anti-inflammation, anti-oxidation, anti-tumor,
Efficacy of black cohosh (Cimicifuga racemosa L.) in treating early symptoms of menopause: a randomized clinical trial
01/11/2013 09:03
Background: This study aims to evaluate the efficacy of Black cohosh (Cimicifuga racemosa L.) in treating early menopausal symptoms. Methods: This randomized, double-blind, placebo-controlled clinical trial was conducted on 84 early post-menopausal p
Flavonoids with alpha-glucosidase inhibitory activities and their contents in the leaves of Morus atropurpurea
14/10/2013 18:11
Background: This study aims to isolate the alpha-glucosidase inhibitory compounds from mulberry leaves (Morus atropurpurea Roxb., Moraceae) and to develop an analytical method for quantification of the compounds. Methods: Four flavonoids, rutin (1),
Anti-Candida properties of asaronaldehyde of Acorus gramineus rhizome and three structural isomers
08/09/2013 12:05
Background: Asaronaldehyde (2, 4, 5-trimethoxybeznaldehyde) is an active component of Acorus gramineus rhizome. This study aims to evaluate the anti-Candida efficacy of asaronaldehyde and its three structural isomers, namely, 2, 3, 4-trimethoxybenzal
Puerarin promotes osteogenesis and inhibits adipogenesis in vitro
21/08/2013 18:39
Background: Puerarin (daidzein 8-C-glucoside) has potential on preventing osteoporosis. This study aims to investigate the effects of puerarin on osteogenesis and adipogenesis in vitro. Methods: CCK-8 assay, alkaline phosphatase (ALP) activity and Al
Evaluation of seven DNA barcodes for differentiating closely related medicinal Gentiana species and their adulterants
20/08/2013 17:07
Background: Species identification of living organisms by standard DNA sequences has been well-accepted. Consortium for the Barcode of Life (CBOL) recommends chloroplast regions rbcL and matK as the DNA barcodes for the land plants. This study aims t
Effects of acupuncture for cancer pain and quality of life -- a case series
30/07/2013 04:48
Background: Many cancer patients seek complementary and alternative medicine (CAM) including acupuncture to manage their cancer-related symptoms or side effects of treatments. Acupuncture is used to manage cancer pain and improve quality of life (QoL
Therapeutic effect of Yang-Xue-Qing-Nao granules on sleep dysfunction in Parkinson's disease
27/07/2013 21:48
Background: This study aimed to evaluate the effects of add-on Yang-Xue-Qing-Nao granules (YXQN) on sleep dysfunction in patients with Parkinson's disease (PD). Methods: PD participants fitted with an actigraph took either YXQN or placebo granules in
Zedoary oil (Ezhu You) inhibits proliferation of AGS cells
28/06/2013 06:05
Background: Zedoary (Curcumae Rhizoma, Ezhu), a Chinese medicinal herb, has been reported to show anticancer activity. This study aims to investigate the effect of zedoary oil (Ezhu You) on the proliferation of AGS cells which is one gastric cancer c
Chemical changes of Angelicae Sinensis Radix and Chuanxiong Rhizoma by wine treatment: chemical profiling and marker selection by gas chromatography coupled with triple quadrupole mass spectrometry
06/06/2013 16:27
Background: Angelicae Sinensis Radix (ASR) and Chuanxiong Rhizoma (CR) can be treated with wine to promote their biological functions in Chinese medicine. Both ASR and CR contain similar volatile chemicals that could be altered after wine treatment.
Anti-hyperglycaemic activity of swietenia macrophylla king (meliaceae) seed extracts in normoglycaemic rats undergoing glucose tolerance tests
17/05/2013 12:30
Background: Swietenia macrophylla King (Meliaceae) is used to treat diabetes mellitus in Malaysia. This study aims to evaluate the anti-hyperglycaemic potential of petroleum ether (PE), chloroform (CE) and methanol (ME) extracts of S. macrophylla see
Developing a diagnostic checklist of traditional Chinese medicine symptoms and signs for psoriasis: a Delphi study
12/05/2013 20:24
Background: Psoriasis is a chronic inflammatory skin disease with a genetic basis. Its ill-defined causes make it difficult to diagnose. This study aims to develop a diagnostic checklist for psoriasis classification in the context of traditional Chin
Time course changes of anti- and pro-apoptotic proteins in apigenin-induced genotoxicity
04/05/2013 16:15
Background: Apigenin (4[prime],5,7-trihydroxyflavone, AP), an active component of many medicinal Chinese herbs, exhibits anticancer properties in vitro and in vivo. This study aims to investigate the genotoxic, cytostatic, and cytotoxic effects of AP
Referral to Chinese medicine practitioners in Australian primary care: a survey of New South Wales rural and regional general practitioners
08/04/2013 23:09
Background: Chinese medicine practitioners (CMPs) play an important part in rural and regional Australian healthcare. A survey was conducted to investigate referral practices between Chinese medicine (CM) and conventional primary health care practiti
Hepatoprotective effect of water extract from Chrysanthemum indicum L. flower
04/04/2013 21:03
Background: Chrysanthemum indicum L. flower (CIF) has been widely used as tea in Korea. This study aims to investigate the hepatoprotective effect of the hot water extract of CIF (HCIF) in in vitro and in vivo systems. Methods: Hepatoprotective activ
Chemical fingerprinting and quantitative constituent analysis of Siwu decoction categorized formulae by UPLC-QTOF/MS/MS and HPLC-DAD
26/03/2013 16:18
Background: Siwu decoction categorized formulae (SWDCF) are widely used for treating gynecological diseases. This study aims to elucidate the differences of bioactive constituents in SWDCF by ultra-high performance liquid chromatography coupled with
Effects of Panax ginseng-containing herbal plasters on compressed intervertebral discs in an in vivo rat tail model
26/03/2013 16:18
Background: Tienchi (Panax notoginseng) has been used in conservative treatments for back pain as a major ingredient of many herbal medicines. This study aims to investigate the effects of a herbal medicine containing tienchi on compressed interverte
Key considerations for conducting Chinese medicine clinical trials in hospitals
26/03/2013 16:18
Conducting clinical trials of Chinese medicines (CM) in hospitals presents challenges for researchers. The success of hospital-based CM clinical trials may be influenced by the protocol design, including the maintenance of CM theory in compliance wit
Changes in the contents of four active diterpenoids at different growth stages in Andrographis paniculata (Burm.f.) Nees (Chuanxinlian)
26/03/2013 16:18
Background: The therapeutic activities of Andrographis paniculata are attributed to four major active diterpenoids: andrographolide (AP1), 14-deoxy-11,12-didehydroandrographolide (AP3), neoandrographolide (AP4), and 14-deoxyandrographolide (AP6). Thi
Oral bioavailability of cantharidin-loaded solid lipid nanoparticles
26/03/2013 16:18
Background: The clinical application of cantharidin (CA) is limited by its insolubility, toxicity and short half-life in circulation. This study aims to achieve a steady and sustained blood concentration--time profile, using solid lipid nanoparticles
Optimization of technology for dietary fiber extraction from Maixiansan by response surface methodology
26/03/2013 16:18
Background: Our study aims to determine whether response surface methodology can optimize the extraction of dietary fiber from Maixiansan. Methods: A Box–Behnken design was employed to optimize the extraction parameters, including α-amylase concen
Effect of KOB03, a polyherbal medicine, on ovalbumin-induced allergic rhinitis in guinea pigs
26/03/2013 16:18
Background: KOB03 is a polyherbal medicine that originated from the oriental prescription for the treatment of chronic allergic diseases such as rhinitis and asthma. This study aims to evaluate the effect of KOB03 on ovalbumin (OVA)-induced allergic
Antioxidant and anti-inflammatory activities of selected medicinal plants and fungi containing phenolic and flavonoid compounds
26/03/2013 16:18
Background: This study aims to determine the relationship between the antioxidant and anti-inflammatory activities of the thirteen herbs and two fungi extracts, and their total phenolic and flavonoid contents. Methods: Antioxidant activities were eva
Metabonomic analysis of water extracts from Chinese and American ginsengs by 1H nuclear magnetic resonance: identification of chemical profile for quality control
26/03/2013 16:18
Background: With the gaining popularity of commercially prepared decoctions of herbal medicines on the market, an objective and efficient way to reveal the authenticity of such products is urgently needed. Previous attempts to use chromatographic or
Annual acknowledgement of manuscript reviewers
20/03/2013 21:57
Contributing reviewersThe editors of Chinese Medicine would like to thank all our reviewers who have contributed to the journal in Volume 7 (2012).