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Recent items - American Journal of Obstetrics & Gynecology

Seeking the mechanism(s) of action for corticosteroids in HELLP syndrome: SMASH study
25/04/2013 16:21
Introduction: Administration of dexamethasone to the hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome patients (10 mg intravenously [IV] every 12 hours) shortens the disease course and reduces maternal morbidity in patient
Maternal magnesium supplementation reduces intrauterine growth restriction and suppresses inflammation in a rat model
25/04/2013 16:21
Objective: Intrauterine growth restriction (IUGR) is associated with increased inflammatory responses. We sought to investigate whether magnesium (Mg) attenuates inflammation and IUGR in a rat model.Study design: Pregnant Wistar rats (12 weeks, gest
First-trimester detection of fetal anomalies in pregestational diabetes using nuchal translucency, ductus venosus Doppler, and maternal glycosylated hemoglobin
25/04/2013 16:21
Objective: The frequency of fetal anomalies in women with pregestational diabetes correlates with their glycemic control. This study aimed to assess the predictive performance of first-trimester fetal nuchal translucency (NT), ductus venosus (DV) D
Long-term alterations in maternal plasma proteome after sFlt1–induced preeclampsia in mice
25/04/2013 16:21
Objective: Preeclampsia is associated with long-term adverse maternal health, such as cardiovascular and metabolic diseases. The objective of this study was to determine whether preeclampsia in a well-characterized animal model that was induced by
Maternal plasma 25-hydroxyvitamin D levels, angiogenic factors, and preeclampsia
25/04/2013 16:21
Objective: The objective of the study was to examine the associations of maternal plasma levels of 25-hydroxyvitamin D [25(OH)D] with angiogenesis and endothelial dysfunction indicators: soluble fms-like tyrosine kinase-1 (sFlt-1), placental growth
Correction
25/04/2013 16:21
January 2013 (vol. 208, no. 1, page 11) Society for Maternal-Fetal Medicine, Simpson LL. Twin-twin transfusion syndrome: SMFM Clinical Guideline. Am J Obstet Gynecol 208;3:3-18.
Significance of growth discordance in appropriately grown twins
25/04/2013 16:21
Objective: We sought to determine the perinatal risks associated with growth discordance in appropriately grown twin gestations. Study Design: We conducted a retrospective cohort study of all twin gestations excluding those complicated by monoamn
DNA methylation at imprint regulatory regions in preterm birth and infection
25/04/2013 16:21
Objective: To aid in understanding long-term health consequences of intrauterine infections in preterm birth, we evaluated DNA methylation at 9 differentially methylated regions that regulate imprinted genes by type of preterm birth (spontaneous pr
Down syndrome maternal serum marker screening after 18 weeks of gestation: a countrywide study
25/04/2013 16:21
Objective: The objective of the study was to evaluate the efficacy of maternal serum markers in detecting Down syndrome after 18 weeks of gestation in women who book late for maternity care in a large national retrospective study. Study Design: D
Modulation of lipopolysaccharide-induced chorioamnionitis by Ureaplasma parvum in sheep
25/04/2013 16:21
Objective: Ureaplasma colonization in the setting of polymicrobial flora is common in women with chorioamnionitis, and is a risk factor for preterm delivery and neonatal morbidity. We hypothesized that Ureaplasma colonization of amniotic fluid woul
Table of Contents
25/04/2013 16:21
Information for readers
25/04/2013 16:21
New tools for an old quest
25/04/2013 16:21
Due in great part to the more than 20 years of groundbreaking work by Lo et al, the long-awaited noninvasive prenatal diagnosis of trisomy 21 is almost at hand, perhaps lacking only a few technical enhancements to reduce or eliminate a small false er
Patients, providers, and politicians: we all bear the weight of the obesity epidemic
25/04/2013 16:21
To say that there is an obesity epidemic is an understatement. The conditions of overweight (body mass index [BMI], 25-29.9 kg/m2) and obesity (BMI, >30 kg/m2) are becoming the norm in the United States and other countries. In the United States, almo
A systematic review of randomized trials assessing human papillomavirus testing in cervical cancer screening
25/04/2013 16:21
Our objective was to assess the sensitivity and specificity of human papillomavirus (HPV) testing for cervical cancer screening in randomized trials. We conducted a systematic literature search of the following databases: MEDLINE, CINAHL, EMBASE, an
Prenatal treatment of congenital adrenal hyperplasia: risks outweigh benefits
25/04/2013 16:21
Prenatal treatment of congenital adrenal hyperplasia by administering dexamethasone to a woman presumed to be carrying an at-risk fetus has been described as safe and effective in several reports. A review of data from animal experimentation and hum
Phenotyping clinical disorders: lessons learned from pelvic organ prolapse
25/04/2013 16:21
Genetic epidemiology, the study of genetic contributions to risk for disease, is an innovative area in medicine. Although research in this arena has advanced in other disciplines, few genetic epidemiological studies have been conducted in obstetrics
Staged endovascular and surgical treatment of slow-flow vulvar venous malformations
25/04/2013 16:21
Objective: The objective of the study was to report our experience in a rare series of treated symptomatic slow-flow vulvar venous malformations (VVMs) using a staged, multidisciplinary approach. Study Design: Consecutive patients with symptomati
A randomized trial comparing conventional and robotically assisted total laparoscopic hysterectomy
25/04/2013 16:21
Objective: The purpose of this study was to compare operative time and intra- and postoperative complications between total laparoscopic hysterectomy and robotic-assisted total laparoscopic hysterectomy. Study Design: This study was a blinded, pr
Metabolomic analysis for first-trimester Down syndrome prediction
25/04/2013 16:21
Objective: The objective of the study was to perform first-trimester maternal serum metabolomic analysis and compare the results in aneuploid vs Down syndrome (DS) pregnancies. Study Design: This was a case-control study of pregnancies between 11
Recurrence of small-for-gestational-age pregnancy: analysis of first and subsequent singleton pregnancies in The Netherlands
25/04/2013 16:21
Objective: Small-for-gestational-age (SGA) neonates are at increased risk of adverse pregnancy outcome. Our objective was to study the recurrence rate of SGA in subsequent pregnancies. Study Design: A prospective national cohort study of all wome
Risk of stillbirth after 37 weeks in pregnancies complicated by small-for-gestational-age fetuses
25/04/2013 16:21
Objective: The evidence for delivering small-for-gestational-age (SGA) fetuses at 37 weeks remains conflicting. We examined the risk of stillbirth per week of gestation beyond 37 weeks for pregnancies complicated by SGA. Study Design: Singleton p
Maternal seizure disorder and risk of adverse pregnancy outcomes
25/04/2013 16:21
Objective: We sought to estimate the association between maternal seizure disorder and adverse pregnancy outcomes. Study Design: We performed a retrospective cohort study of singleton, nonanomalous pregnancies. Women with self-reported seizure di
Is early amniotomy in nulliparous labor induction really efficient?
25/04/2013 16:21
Thank you for publishing an article about the concept of early amniotomy in nulliparous labor induction. It is really a special interest topic in the field of obstetrics that most of us considerably encounter in clinical practice every day. I also co
Reply
25/04/2013 16:21
We thank Dr Kasapoglu for his interest in our article on the role of early amniotomy in nulliparous labor induction. Dr Kasapoglu raises 2 points in his letter. First, he has some concerns about our sample size as it relates to one of the primary o
Trends in the rate of invasive procedures after the addition of the intrauterine tamponade test to a protocol for management of severe postpartum hemorrhage
25/04/2013 16:21
We read with interest the recent article from Laas et al. This was a really interesting study concerning a new treatment of a main cause of maternal death. We want to congratulate the authors for evaluating the efficiency of the intrauterine tampon
Reply
25/04/2013 16:21
We thank Hequet et al for their comments regarding our recent article. We are happy to clarify that our cohort study included only inpatients specifically to avoid a recruitment bias (ie, we did not include patients with severe postpartum hemorrhag
Discussion: ‘Ovarian epithelial carcinoma with pelvic endometriosis,’ by Wang et al
25/04/2013 16:21
In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed:Wang S, Qui L, Lang JH, et al. Clinical ana
Term delivery following tuboovarian abscess after in vitro fertilization and embryo transfer
25/04/2013 16:21
A tuboovarian abscess (TOA) during pregnancy following oocyte retrieval is extremely rare. We report a rare case of pregnancy complicated by the development of a TOA following in vitro fertilization-embryo transfer that was treated successfully with
Safe conception for HIV-discordant couples: insemination with processed semen from the HIV-infected partner
25/04/2013 16:21
Objective: The objective of the study was to evaluate the safety of semen washing with intrauterine insemination (SW-IUI) for achieving pregnancy when the man is human immunodeficiency virus (HIV) infected and the woman is HIV negative. Study Desi
Seasonal variations of human sperm cells among 6455 semen samples: a plausible explanation of a seasonal birth pattern
25/04/2013 16:21
Objective: To compare the different sperm parameters according to season of the year on sperm production day and the season 70 days prior (during spermatogenesis). Study Design: Retrospective Andrology Laboratory data comparison. A total of 6455
Correction
25/04/2013 16:21
Supplement to January 2013 (vol. 208, no. 1, page S93) The byline in an abstract published in the January 2013 supplement to the Journal representing the program of the 33rd annual meeting of the Society for Maternal-Fetal Medicine omitted the name
Obesity management in gynecologic cancer survivors: provider practices and attitudes
25/04/2013 16:21
Objective: Obesity is associated with the development and risk of death from several women's cancers. The study objective was to describe and compare oncologic providers' attitudes and practices as they relate to obesity counseling and management i
A contemporary analysis of epidemiology and management of vaginal intraepithelial neoplasia
25/04/2013 16:21
Objective: The purpose of this study was to review a large cohort of patients with vaginal intraepithelial neoplasia (VAIN) and to analyze the epidemiology and outcomes with various treatment modalities. Study Design: A retrospective chart review
Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic endometriosis
25/04/2013 16:21
Objectives: To explore the differences between women with endometiosis associated ovarian cancer and typical epithelial ovarian cancer. Study Design: The medical charts of total 226 patients with epithelial ovarian cancer treated at Peking Union
Ovarian epithelial carcinoma with pelvic endometriosis: Wang et al
25/04/2013 16:21
The article below summarizes a roundtable discussion of a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed:Wang S, Qui L, Lang JH, et al. Clinica
The case of the sinister spores: The patient was hospitalized for a menacing infection in the second trimester of pregnancy
25/04/2013 16:21
A 30-year-old Filipino woman was at approximately 14 weeks' gestation in her first pregnancy when she presented to her obstetrician with a 1 week history of headaches, nausea, and vomiting. At that time, she was diagnosed with migraine headaches. Abo
What is a laborist?
25/04/2013 16:21
We read with great pleasure the article by Olson et al in the August 2012 issue. According to their definition, I am a part-time, full-service hospitalist. My time as a laborist is 5-37% of my weekly hours in the hospital. We share the belief that it
17-hydroxy progesterone caproate for preterm labor prevention: final blood levels
27/03/2013 12:24
We read with great interest the study correlating 17-hydroxy progesterone caproate (17-OHPC) levels with preterm delivery. We have the following comments: The levels of 17-OHPC correlated with progesterone and hydroxy-progesterone levels. Is it pos
Reply
27/03/2013 12:24
We thank Drs Usta, Usta, and Nassar for their questions and comments. The method that was used to assay 17-hydroxyprogesterone caproate (HPLC-MS/MS) distinguishes progesterone from 17-hydroxyprogesterone and 17-hydroxyprogesterone caproate. We are co
Discussion: ‘Hypertension and antihypertensives in pregnancy,' by Orbach et al
27/03/2013 12:24
In the roundtable that follows, clinicians discuss a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Orbach H, Matok I, Gorodischer R, et al. H
Lingual thrombosis in a woman with antiphospholipid syndrome
27/03/2013 12:24
A 28-year-old woman, 34 weeks pregnant, with previously diagnosed antiphospholipid syndrome, presents with vesicular tongue lesions treated as herpes outbreak and new onset of preeclampsia. Tongue biopsy preformed postpartum after induction of labor
Correction
27/03/2013 12:24
July 2012 (vol. 207, no. 1, page 39) Westhoff CL, Torgal AH, Mayeda ER, et al. Pharmacokinetics and ovarian suppression during use of a contraceptive vaginal ring in normal-weight and obese women. Am J Obstet Gynecol 2012;207:39.e1-6.
Factors associated with wound complications in women with obstetric anal sphincter injuries (OASIS)
27/03/2013 12:24
Objective: We sought to determine factors associated with perineal wound complications in women with obstetric anal sphincter injuries (OASIS). Study Design: A retrospective chart review of women who sustained an OASIS from Nov. 2, 2005, through
Impact of family history on choosing risk-reducing surgery among BRCA mutation carriers
27/03/2013 12:24
Objective: Despite substantial survival benefits of risk-reducing mastectomy (RRM) and risk-reducing bilateral salpingo-oophorectomy (RRBSO) among BRCA mutation carriers, only a minority elect to undergo these procedures. This study investigates fa
Correction
27/03/2013 12:24
Supplement to October 2011 (vol. 205, no. 4, page S21) Jeffrey T. Jensen, MD, MPH, has supplied a conflict of interest statement to replace the “reports no conflict” statement published with his article in a supplement to the October 2011 issue
Correction
27/03/2013 12:24
October 2012 (vol. 207, no. 4, page 288) The name and academic degrees of the second author of an article published in the October 2012 issue of the Journal (Pneumonia and pregnancy outcomes: a nationwide population-based study. Am J Obstet Gynecol
Hypertension and antihypertensives in pregnancy: Orbach et al
27/03/2013 12:24
The article below summarizes a roundtable discussion of a study published in this issue of the Journal in light of its methodology, relevance to practice, and implications for future research. Article discussed: Orbach H, Matok I, Gorodischer R, et
A gravid development: Should the desire to maintain fertility determine treatment for profuse bleeding in pregnancy?
27/03/2013 12:24
A 33-year-old woman, 5 days into week 17 of her sixth pregnancy was treated in the Emergency Department with heavy vaginal bleeding. Placenta accreta had already been suspected based on a 15-week ultrasound image (). Her obstetric history included 2
Management of intravascular leiomyomatosis: Laparoscopic surgery for ordinary uterine fibroids led to an extraordinary finding
27/03/2013 12:24
An unexpected diagnosis of intravascular leiomyomatosis was made during a laparoscopic procedure. As the extent of the disease was unknown, the initial procedure was limited to laparoscopic hysterectomy and salpingo-oophorectomy. Postoperative compu
Unintended pregnancy among active-duty servicewomen and veterans
27/03/2013 12:24
We applaud the efforts made by the authors to review the published literature on unintended pregnancy and highlight these outcomes in active-duty servicewomen and veterans. We also recognize that the rate of unintended pregnancy has remained at appro
Reply
27/03/2013 12:24
We appreciate the points raised by Nielsen, Towers, and O'Boyle and applaud their ongoing efforts to ensure the best possible health of our troops and their families. We acknowledge that many medical schools and residency programs provide limited t
Preconceptional laparoscopic abdominal cerclage: a multicenter cohort study
27/03/2013 12:24
The article “Preconceptional laparoscopic abdominal cerclage: a multicenter cohort study” describes the effectiveness of prepregnancy laparoscopic abdominal cerclage (LAC). Total fetal survival rate was reported to be 90%, which is similar to tha
Reply
27/03/2013 12:24
We appreciate the comments of Drs Salmeen and Parer regarding our recent article. First, Drs Salmeen and Parer have concerns on the fetal survival rate calculation that we used. We agree that, in the most ideal situation, it should be calculated by