Recent items - Rheumatology
Patient-level clinically meaningful improvements in activities of daily living and pain after total hip arthroplasty: data from a large US institutional registry
11/05/2013 14:09
Objective. To characterize patient-level clinically meaningful improvements in pain and limitation of key activities of daily living (ADLs) after primary or revision total hip arthroplasty (THA). Methods. We analysed prospectively collected data fro
11/05/2013 14:09
Objective. To characterize patient-level clinically meaningful improvements in pain and limitation of key activities of daily living (ADLs) after primary or revision total hip arthroplasty (THA). Methods. We analysed prospectively collected data fro
Pregnancy outcomes in women with juvenile idiopathic arthritis: a population-based study
11/05/2013 14:09
Objective. The aim of this study is to describe pregnancy outcomes among women with JIA. Methods. Women who gave birth in New South Wales (NSW), Australia, were linked to hospital discharge records from 2000 to 2010. Women with an ICD-10-AM code of
11/05/2013 14:09
Objective. The aim of this study is to describe pregnancy outcomes among women with JIA. Methods. Women who gave birth in New South Wales (NSW), Australia, were linked to hospital discharge records from 2000 to 2010. Women with an ICD-10-AM code of
Rates of adherence and persistence with allopurinol therapy among gout patients in Israel
11/05/2013 14:09
Objective. To assess the adherence and persistence with allopurinol therapy among gout patients and to identify risk factors for therapy discontinuation. Methods. The study population included adults in Maccabi Healthcare Services, a 2-million membe
11/05/2013 14:09
Objective. To assess the adherence and persistence with allopurinol therapy among gout patients and to identify risk factors for therapy discontinuation. Methods. The study population included adults in Maccabi Healthcare Services, a 2-million membe
Efficacy and safety of leflunomide in DMARD-naive patients with early rheumatoid arthritis: comparison of a loading and a fixed-dose regimen
11/05/2013 14:09
Objective. To assess the efficacy of LEF administered with or without a loading dose in DMARD-naïve patients with early RA. Methods. This multicentre, double-blind, randomized clinical trial included adults with RA diagnosed within 6 months (AC
11/05/2013 14:09
Objective. To assess the efficacy of LEF administered with or without a loading dose in DMARD-naïve patients with early RA. Methods. This multicentre, double-blind, randomized clinical trial included adults with RA diagnosed within 6 months (AC
Efficacy of ambrisentan in the treatment of digital ulcers in patients with systemic sclerosis: a preliminary study
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A novel arthritis in vivo fluorescence optical imaging technology pushed to the limits
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Severe deafness associated with Crohn's disease and spondylarthropathy: successful treatment with anti-TNF
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Treatment of fracture non-union in a young adult with combination anabolic and anti-resorptive bone therapy
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Predictors of response to intra-articular steroid injections in knee osteoarthritis--a systematic review
11/05/2013 14:09
Objective. IA steroid injections (IASIs) have been shown to relieve pain in knee OA and are widely used in clinical practice. There is, however, evidence of some variation in response. Knowledge of predictors of response could aid in the selection o
11/05/2013 14:09
Objective. IA steroid injections (IASIs) have been shown to relieve pain in knee OA and are widely used in clinical practice. There is, however, evidence of some variation in response. Knowledge of predictors of response could aid in the selection o
Body weight at early and middle adulthood, weight gain and persistent overweight from early adulthood are predictors of the risk of total knee and hip replacement for osteoarthritis
11/05/2013 14:09
Objectives. To examine the relationships between weight at early and middle adulthood and adult weight gain and the risk of total knee and hip replacement for OA. Methods. At baseline interview during 1990–94, 38 149 participants [mean age 54.
11/05/2013 14:09
Objectives. To examine the relationships between weight at early and middle adulthood and adult weight gain and the risk of total knee and hip replacement for OA. Methods. At baseline interview during 1990–94, 38 149 participants [mean age 54.
Subcutaneous abatacept for the treatment of rheumatoid arthritis
11/05/2013 14:09
The efficacy, safety and tolerability of i.v. abatacept are well established in patients with active RA. A s.c. abatacept formulation is now available in some countries. Here, we review clinical data for s.c. abatacept. Six trials are presented (Pha
11/05/2013 14:09
The efficacy, safety and tolerability of i.v. abatacept are well established in patients with active RA. A s.c. abatacept formulation is now available in some countries. Here, we review clinical data for s.c. abatacept. Six trials are presented (Pha
Delphinidin inhibits IL-1{beta}-induced activation of NF-{kappa}B by modulating the phosphorylation of IRAK-1Ser376 in human articular chondrocytes
11/05/2013 14:09
Objective. In OA, there is enhanced expression of pro-inflammatory cytokines such as IL-1β in the affected joint. Delphinidin, an anthocyanidin found in pigmented fruits and vegetables, has been shown to possess anti-inflammatory and antioxidan
11/05/2013 14:09
Objective. In OA, there is enhanced expression of pro-inflammatory cytokines such as IL-1β in the affected joint. Delphinidin, an anthocyanidin found in pigmented fruits and vegetables, has been shown to possess anti-inflammatory and antioxidan
IL-34 is overexpressed in the inflamed salivary glands of patients with Sjogren's syndrome and is associated with the local expansion of pro-inflammatory CD14brightCD16+ monocytes
11/05/2013 14:09
Objectives. To investigate the expression of IL-34 in labial salivary glands (LSGs) of patients with primary SS (p-SS) and its role in inducing a pro-inflammatory monocyte phenotype. Methods. LSG biopsies were obtained from 20 patients with p-SS and
11/05/2013 14:09
Objectives. To investigate the expression of IL-34 in labial salivary glands (LSGs) of patients with primary SS (p-SS) and its role in inducing a pro-inflammatory monocyte phenotype. Methods. LSG biopsies were obtained from 20 patients with p-SS and
Hyperuricaemia elevates circulating CCL2 levels and primes monocyte trafficking in subjects with inter-critical gout
11/05/2013 14:09
Objective. To investigate the effect of hyperuricaemia on serum chemokine (C-C motif) ligand 2 (CCL2) levels and blood monocytes in people with gout. Methods. Whole blood was collected from subjects with a history of acute or chronic gout but not cu
11/05/2013 14:09
Objective. To investigate the effect of hyperuricaemia on serum chemokine (C-C motif) ligand 2 (CCL2) levels and blood monocytes in people with gout. Methods. Whole blood was collected from subjects with a history of acute or chronic gout but not cu
What can asymptomatic hyperuricaemia and systemic inflammation in the absence of gout tell us?
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Corticosteroid injections in osteoarthritis: should we care about predicting response?
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Friend or foe: high bone mineral density on routine bone density scanning, a review of causes and management
11/05/2013 14:09
A finding of high BMD on routine DXA scanning is not infrequent and most commonly reflects degenerative disease. However, BMD increases may also arise secondary to a range of underlying disorders affecting the skeleton. Although low BMD increases fr
11/05/2013 14:09
A finding of high BMD on routine DXA scanning is not infrequent and most commonly reflects degenerative disease. However, BMD increases may also arise secondary to a range of underlying disorders affecting the skeleton. Although low BMD increases fr
High bone mass is associated with an increased prevalence of joint replacement: a case-control study
11/05/2013 14:09
Objective. Epidemiological studies have shown an association between OA and increased BMD. To explore the nature of this relationship, we examined whether the risk of OA is increased in individuals with high bone mass (HBM), in whom BMD is assumed t
11/05/2013 14:09
Objective. Epidemiological studies have shown an association between OA and increased BMD. To explore the nature of this relationship, we examined whether the risk of OA is increased in individuals with high bone mass (HBM), in whom BMD is assumed t
Telomere length in patients with systemic lupus erythematosus and its associations with carotid plaque
11/05/2013 14:09
Objective. To evaluate telomere length (TL) between patients with SLE and healthy controls and to test if TL is associated with carotid plaque. Methods. A pilot study of 154 patients with SLE and 152 controls was performed from the SOLVABLE (Study o
11/05/2013 14:09
Objective. To evaluate telomere length (TL) between patients with SLE and healthy controls and to test if TL is associated with carotid plaque. Methods. A pilot study of 154 patients with SLE and 152 controls was performed from the SOLVABLE (Study o
Predictors for the 5-year risk of serious infections in patients with rheumatoid arthritis treated with anti-tumour necrosis factor therapy: a cohort study in the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry
11/05/2013 14:09
Objective. The use of TNF inhibitors leads to an increased risk of serious infections in RA. Predicting this risk would facilitate the prevention of serious infections. The objective of this study was to identify which factors are predictive of the
11/05/2013 14:09
Objective. The use of TNF inhibitors leads to an increased risk of serious infections in RA. Predicting this risk would facilitate the prevention of serious infections. The objective of this study was to identify which factors are predictive of the
Effect on bone turnover markers of once-yearly intravenous infusion of zoledronic acid versus daily oral risedronate in patients treated with glucocorticoids
11/05/2013 14:09
Objective. Long-term glucocorticoid use is accompanied by rapid bone loss; however, early treatment with bisphosphonates prevents bone loss and reduces fracture risk. The aim of this study was to examine the effects of two bisphosphonates, i.v. zole
11/05/2013 14:09
Objective. Long-term glucocorticoid use is accompanied by rapid bone loss; however, early treatment with bisphosphonates prevents bone loss and reduces fracture risk. The aim of this study was to examine the effects of two bisphosphonates, i.v. zole
Low risk of renal flares and negative outcomes in women with lupus nephritis conceiving after switching from mycophenolate mofetil to azathioprine
11/05/2013 14:09
Objective. MMF is teratogenic and needs to be replaced before pregnancy. This change may lead to flares. Our aim was to determine the risk of renal flares in women with LN who switched treatment from MMF to AZA before conception and to evaluate the
11/05/2013 14:09
Objective. MMF is teratogenic and needs to be replaced before pregnancy. This change may lead to flares. Our aim was to determine the risk of renal flares in women with LN who switched treatment from MMF to AZA before conception and to evaluate the
The association of adipokine levels in plasma and synovial fluid with the severity of knee osteoarthritis
11/05/2013 14:09
Objective. We sought to determine the association between plasma and SF levels of leptin and adiponectin in patients with knee OA. Methods. Plasma and SF levels of adipokines and soluble leptin receptor (sOB-R) were determined by ELISA in 96 patient
11/05/2013 14:09
Objective. We sought to determine the association between plasma and SF levels of leptin and adiponectin in patients with knee OA. Methods. Plasma and SF levels of adipokines and soluble leptin receptor (sOB-R) were determined by ELISA in 96 patient
Characteristics of Sjogren's syndrome in rheumatoid arthritis
11/05/2013 14:09
Objective. To compare features of SS in RA with primary SS and RA without SS. Methods. Patients hospitalized between January 2007 and December 2010 were retrospectively studied. Seventy-four cases of overlap RA and SS (RA/SS) among 509 cases of RA w
11/05/2013 14:09
Objective. To compare features of SS in RA with primary SS and RA without SS. Methods. Patients hospitalized between January 2007 and December 2010 were retrospectively studied. Seventy-four cases of overlap RA and SS (RA/SS) among 509 cases of RA w
Comparison of three imaging techniques in diagnosis of chondrocalcinosis of the knees in calcium pyrophosphate deposition disease
11/05/2013 14:09
Objective. To study the role of different imaging modalities, ultrasonography, conventional radiography (CR) and CT, in visualization of chondrocalcinosis of the knees in patients with CPDD. Methods. Twenty-five patients (14 males and 11 females) wi
11/05/2013 14:09
Objective. To study the role of different imaging modalities, ultrasonography, conventional radiography (CR) and CT, in visualization of chondrocalcinosis of the knees in patients with CPDD. Methods. Twenty-five patients (14 males and 11 females) wi
Gastrointestinal motility disorder assessment in systemic sclerosis
11/05/2013 14:09
Objectives. SSc is a clinically heterogeneous and generalized disease, characterized by thickness of the connective tissue of the skin and internal organs, such as the digestive tract, impairing gastrointestinal (GI) motility. Our aim is to evaluate
11/05/2013 14:09
Objectives. SSc is a clinically heterogeneous and generalized disease, characterized by thickness of the connective tissue of the skin and internal organs, such as the digestive tract, impairing gastrointestinal (GI) motility. Our aim is to evaluate
Current evidence of methotrexate efficacy in childhood chronic uveitis: a systematic review and meta-analysis approach
19/04/2013 13:33
Objective. To summarize evidence regarding the effectiveness of MTX in the treatment of childhood autoimmune chronic uveitis (ACU). Methods. A systematic search of articles between January 1990 and June 2011 was conducted using EMBASE, Ovid MEDLINE,
19/04/2013 13:33
Objective. To summarize evidence regarding the effectiveness of MTX in the treatment of childhood autoimmune chronic uveitis (ACU). Methods. A systematic search of articles between January 1990 and June 2011 was conducted using EMBASE, Ovid MEDLINE,
Who are the patients with early arthritis with worse than death scores on the EQ-5D? Results from the ESPOIR cohort
19/04/2013 13:33
Objectives. The EQ-5D is a five-dimension multi-attribute questionnaire widely used to calculate quality-adjusted life-year scores. We aimed to describe patients with early arthritis (EA) and EQ-5D < 0, a state worse than death, at baseline and o
19/04/2013 13:33
Objectives. The EQ-5D is a five-dimension multi-attribute questionnaire widely used to calculate quality-adjusted life-year scores. We aimed to describe patients with early arthritis (EA) and EQ-5D < 0, a state worse than death, at baseline and o
An evaluation of molecular and clinical remission in rheumatoid arthritis by assessing radiographic progression
19/04/2013 13:33
Objectives. To determine whether molecular remission defined by a multi-biomarker disease activity (MBDA) score predicts a reduced risk of joint damage progression, and whether the MBDA score can augment existing classifications of remission. Method
19/04/2013 13:33
Objectives. To determine whether molecular remission defined by a multi-biomarker disease activity (MBDA) score predicts a reduced risk of joint damage progression, and whether the MBDA score can augment existing classifications of remission. Method
Long-term follow-up in lupus nephritis patients treated with rituximab--clinical and histopathological response
19/04/2013 13:33
Objective. To investigate the long-term clinical, histological and serological affects of B-cell-depleting therapy (BCDT) in patients with LN refractory to conventional treatment. Methods. Twenty-five patients, followed for a mean time of 36 months
19/04/2013 13:33
Objective. To investigate the long-term clinical, histological and serological affects of B-cell-depleting therapy (BCDT) in patients with LN refractory to conventional treatment. Methods. Twenty-five patients, followed for a mean time of 36 months
The protective effect of alcohol on developing rheumatoid arthritis: a systematic review and meta-analysis
19/04/2013 13:33
Objectives. Our aim was to establish whether alcohol protects against RA development and to determine whether this effect is influenced by alcohol dose, duration and serological status through systematically reviewing the literature and undertaking
19/04/2013 13:33
Objectives. Our aim was to establish whether alcohol protects against RA development and to determine whether this effect is influenced by alcohol dose, duration and serological status through systematically reviewing the literature and undertaking
Pattern of demyelination occurring during anti-TNF-{alpha} therapy: a French national survey
19/04/2013 13:33
Objective. To determine the pattern of demyelinating disorders (DDs) occurring during anti-TNF-α therapy. Methods. Between June 2005 and April 2008, 1800 French rheumatologists and internists were contacted to report cases of DDs occurring in
19/04/2013 13:33
Objective. To determine the pattern of demyelinating disorders (DDs) occurring during anti-TNF-α therapy. Methods. Between June 2005 and April 2008, 1800 French rheumatologists and internists were contacted to report cases of DDs occurring in
Orbital masses in granulomatosis with polyangiitis are associated with a refractory course and a high burden of local damage
19/04/2013 13:33
Objectives. To identify and characterize patients with orbital masses in a monocentric cohort of 1142 GPA patients followed up from 1990 until the end of 2010 with regard to disease stage, local orbital inflammation, course of disease and outcome an
19/04/2013 13:33
Objectives. To identify and characterize patients with orbital masses in a monocentric cohort of 1142 GPA patients followed up from 1990 until the end of 2010 with regard to disease stage, local orbital inflammation, course of disease and outcome an
Autonomous online health assessment questionnaire registry in daily clinical practice
19/04/2013 13:33
Objective. Tight control in RA necessitates frequent disease monitoring; patients might participate by self-assessment of their functional status. Therefore, we assessed the feasibility and acceptability of autonomous online registry of physical fun
19/04/2013 13:33
Objective. Tight control in RA necessitates frequent disease monitoring; patients might participate by self-assessment of their functional status. Therefore, we assessed the feasibility and acceptability of autonomous online registry of physical fun
Methotrexate for pain relief in knee osteoarthritis: an open-label study
19/04/2013 13:33
Objective. Synovitis is very common in knee OA and associated with pain. This open-label study evaluated an anti-synovitis therapy, MTX, for pain relief in knee OA. Methods. Inclusion criteria included pain visual analogue scale (VAS) >40/100 mm,
19/04/2013 13:33
Objective. Synovitis is very common in knee OA and associated with pain. This open-label study evaluated an anti-synovitis therapy, MTX, for pain relief in knee OA. Methods. Inclusion criteria included pain visual analogue scale (VAS) >40/100 mm,
The occurrence of lower limb enthesopathy in coeliac disease patients without clinical signs of articular involvement
19/04/2013 13:33
Objective. Coeliac disease (CD) is a systemic autoimmune condition induced by gluten consumption in genetically predisposed people, affecting ~1% of the general population. In the literature, there are many studies that report the association betwee
19/04/2013 13:33
Objective. Coeliac disease (CD) is a systemic autoimmune condition induced by gluten consumption in genetically predisposed people, affecting ~1% of the general population. In the literature, there are many studies that report the association betwee
High-resolution [18F]fluoride positron emission tomography of the distal interphalangeal joint in psoriatic arthritis--a bone-enthesis-nail complex
19/04/2013 13:33
Objective. This study used high-resolution PET to explore the pattern of DIP joint bone metabolism to test the hypothesis that the nail was functionally integrated with the bone, based on patterns of distal phalange (DP) bone metabolism in PsA compa
19/04/2013 13:33
Objective. This study used high-resolution PET to explore the pattern of DIP joint bone metabolism to test the hypothesis that the nail was functionally integrated with the bone, based on patterns of distal phalange (DP) bone metabolism in PsA compa
All-cause hospitalizations in systemic lupus erythematosus from a large Canadian referral centre
19/04/2013 13:33
Objective. To determine factors affecting morbidity and mortality in a contemporary cohort of hospitalized SLE patients and estimate the rate of SLE hospitalization. Methods. A retrospective chart review was done on all patients admitted to London H
19/04/2013 13:33
Objective. To determine factors affecting morbidity and mortality in a contemporary cohort of hospitalized SLE patients and estimate the rate of SLE hospitalization. Methods. A retrospective chart review was done on all patients admitted to London H
Idiopathic hand osteoarthritis vs haemochromatosis arthropathy--a clinical, functional and radiographic study
19/04/2013 13:33
Objective. Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison wi
19/04/2013 13:33
Objective. Haemochromatosis arthropathy is a secondary OA and the most frequent and earliest clinical presentation of hereditary haemochromatosis (HH). The aim of this study was to perform a direct clinical, functional and radiographic comparison wi
Medical and psychological comorbidity predicts poor pain outcomes after total knee arthroplasty
19/04/2013 13:33
Objective. To study comorbidity correlates of moderate to severe pain after total knee arthroplasty (TKA). Methods. We analysed prospectively collected Total Joint Registry data to examine whether medical (heart disease, peripheral vascular disease,
19/04/2013 13:33
Objective. To study comorbidity correlates of moderate to severe pain after total knee arthroplasty (TKA). Methods. We analysed prospectively collected Total Joint Registry data to examine whether medical (heart disease, peripheral vascular disease,
Psychometric properties of the Norwegian version of the Patient Generated Index in patients with rheumatic diseases participating in rehabilitation or self-management programmes
19/04/2013 13:33
Objective. In rehabilitation, treatment is individually tailored to each patient’s goals. Individualized instruments allow patients to choose domains that they consider important, which may make them particularly appropriate as evaluative tool
19/04/2013 13:33
Objective. In rehabilitation, treatment is individually tailored to each patient’s goals. Individualized instruments allow patients to choose domains that they consider important, which may make them particularly appropriate as evaluative tool
Improvement in deployment of MRI of the sacroiliac joints in patients suspected for spondyloarthritis using a targeted intervention: a case study
19/04/2013 13:33
Objective. To assess characteristics of deployment of MRI of the SI joints (MR-SI) in patients with suspected axial spondyloarthritis (SpA) before and after a targeted intervention. Methods. In a retrospective chart review study, all MR-SI performed
19/04/2013 13:33
Objective. To assess characteristics of deployment of MRI of the SI joints (MR-SI) in patients with suspected axial spondyloarthritis (SpA) before and after a targeted intervention. Methods. In a retrospective chart review study, all MR-SI performed
Low prevalence of coeliac disease in patients with systemic sclerosis: a cross-sectional study of a registry cohort
19/04/2013 13:33
Objectives. Two prior studies suggested that coeliac disease (CD) has a higher prevalence rate (8%) in SSc than in the general population (1%), but these studies were limited by small numbers and the use of traditional coeliac screening antibody tes
19/04/2013 13:33
Objectives. Two prior studies suggested that coeliac disease (CD) has a higher prevalence rate (8%) in SSc than in the general population (1%), but these studies were limited by small numbers and the use of traditional coeliac screening antibody tes
The relationship between EQ-5D, HAQ and pain in patients with rheumatoid arthritis
19/04/2013 13:33
Objective. This study aims to provide robust estimates of EQ-5D as a function of the HAQ and pain in patients with RA. Method. Repeated observations were made of patients diagnosed with RA in a US observational cohort (n = 100 398 observations) who
19/04/2013 13:33
Objective. This study aims to provide robust estimates of EQ-5D as a function of the HAQ and pain in patients with RA. Method. Repeated observations were made of patients diagnosed with RA in a US observational cohort (n = 100 398 observations) who
Serum rituximab levels and efficiency of B cell depletion: differences between patients with rheumatoid arthritis and systemic lupus erythematosus
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Acute natural killer cell pneumonia in a patient transplanted with autologous haematopoietic stem cells for systemic sclerosis
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