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Recent items - Pediatric Rheumatology

The involvement of the vasa vasorum in the development of vasculitis in animal model of Kawasaki disease
30/03/2014 07:59
Background: Kawasaki Disease (KD) involves a diffuse and systemic vasculitis of unknown etiology that mainly affects infants and children. Although a considerable number of analyses of the clinical, histopathological and molecular biological details
Adolescent obesity, joint pain, and hypermobility
29/03/2014 09:30
Background: Obesity associated with joint pain of the lower extremities is likely due to excessive mechanical load on weight bearing joints. Additional mechanical factors may explain the association between obesity and joint pain.FindingsWe character
Feasibility of an online and a face-to-face version of a self-management program for young adults with a rheumatic disease: experiences of young adults and peer leaders
26/03/2014 04:51
Background: Based on the self-efficacy theory, an online and a face-to-face self-management programs 'Challenge your Arthritis' for young adults with a rheumatic disease have recently been developed. These two courses are led by young peer leaders. T
Cervical spine involvement in patients with juvenile idiopathic arthritis - MRI follow-up study
04/03/2014 22:04
Background: To describe MRI and clinical findings in patients with juvenile idiopathic arthritis with cervical spine involvement at onset and follow-up under therapy. Methods: 13 patients with signs of cervical spine involvement in juvenile idiopathi
Current pediatric rheumatology fellowship training in the United States: what fellows actually do
10/02/2014 08:31
Background: Pediatric Rheumatology (PR) training in the US has existed since the 1970's. In the early 1990's, the training was formalized into a three year training program by the American College of Graduate Medical Education (ACGME) and American Bo
Reviewer Acknowledgement 2013
01/02/2014 02:36
Contributing reviewersThe Editors of Pediatric Rheumatology would like to thank all our reviewers who have contributed to the journal in Volume 11 (2013).
Results of a multinational survey regarding the diagnosis and treatment of temporomandibular joint involvement in juvenile idiopathic arthritis
25/01/2014 11:01
Background: Temporomandibular joint (TMJ) involvement occurs in up to 80% of patients with juvenile idiopathic arthritis (JIA). Currently they are no standardized procedures regarding diagnosis and treatment of this common complication of JIA. The ai
MEFV gene mutations and cardiac phenotype in children with familial Mediterranean fever: a cohort study
17/01/2014 03:54
Background: Familial Mediterranean fever (FMF) is the most common autoinflammatory disorder in the world. It is characterized by recurrent febrile inflammatory attacks of serosal and synovial membranes. MEFV gene mutations are responsible for the dis
The pro-inflammatory potential of T cells in juvenile-onset systemic lupus erythematosus
16/01/2014 17:13
Background: T cells are important to systemic lupus erythematosus (SLE) disease progression. This study determined the pro-inflammatory potential of T cells within the rare condition juvenile-onset SLE (JSLE).MethodIL-17A and Th1/Th2-related cytokine
Prolonged improvement of childhood onset systemic lupus erythematosus following systematic administration of rituximab and cyclophosphamide
15/01/2014 04:02
Background: Although the combination of cyclophosphamide and rituximab has been utilized in case reports, there are no previous reports of the long term outcome of SLE treated systematically with this regimen. We report a pilot study to evaluate the
Juvenile dermatomyositis in South African children is characterised by frequent dystropic calcification: a cross sectional study
07/01/2014 23:18
Background: To describe Juvenile dermatomyositis (JDM) that has rarely been reported in Sub-Saharan Africa in children. Methods: Retrospective record review of children with JDM attending a tertiary hospital in South Africa. Results: Twenty-one child
Gout in a 15-year-old boy with juvenile idiopathic arthritis: a case study
06/01/2014 14:01
Joint pain is a common complaint in pediatrics and is most often attributed to overuse or injury. In the face of persistent, severe, or recurrent symptoms, the differential typically expands to include bony or structural causes versus rheumatologic c
Assessment of disease activity by patients with juvenile idiopathic arthritis and the parents compared to the assessment by pediatric rheumatologists
24/12/2013 19:34
Background: Self assessment of arthritis is important for recognition of disease activity and early initiation of therapy. Proper interpretation of physical symptoms is necessary for this. The purpose was to investigate the assessment by patients and
Autoinflammatory bone disorders with special focus on chronic recurrent multifocal osteomyelitis (CRMO)
23/12/2013 11:15
Sterile bone inflammation is the hallmark of autoinflammatory bone disorders, including chronic nonbacterial osteomyelitis (CNO) with its most severe form chronic recurrent multifocal osteomyelitis (CRMO). Autoinflammatory osteopathies are the result
Safety and feasibility of a home-based six week resistance training program in juvenile idiopathic arthritis
21/12/2013 00:08
Background: Juvenile idiopathic arthritis (JIA), among the most common chronic diseases of childhood, can be associated with attenuated physical activity levels, reduced fitness, decreased functionality and pain. This pilot study aimed to determine t
Profiling risk factors for chronic uveitis in juvenile idiopathic arthritis: a new model for EHR-based research
03/12/2013 22:06
Background: Juvenile idiopathic arthritis is the most common rheumatic disease in children. Chronic uveitis is a common and serious comorbid condition of juvenile idiopathic arthritis, with insidious presentation and potential to cause blindness. Kno
pGALS - paediatric Gait Arms Legs and Spine - A simple examination of the musculoskeletal system
12/11/2013 19:16
We describe pGALS (paediatric Gait, Arms, Legs and Spine) - a simple quick musculoskeletal assessment to distinguish abnormal from normal joints in children and young people. The use of pGALS is aimed at the non-specialist in paediatric musculoskelet
The pediatric rheumatology quality of life scale: validation of the English version in a US cohort of juvenile idiopathic arthritis
08/11/2013 20:05
Background: This study aims to validate the English version of the Pediatric Rheumatology Quality of Life Scale (PRQL), a concise Health Related Quality of Life (HRQoL) measure, in a US cohort of children with juvenile idiopathic arthritis (JIA). Met
Hypergammaglobulinemia in the pediatric population as a marker for underlying autoimmune disease: a retrospective cohort study
01/11/2013 12:23
Background: The significance of hypergammaglobulinemia as a marker of immune activation is unknown, as a differential diagnosis for hypergammaglobulinemia in children has not been adequately established. The goal of this study was to identify conditi
The identification of a novel splicing mutation in C1qB in a Japanese family with C1q deficiency: a case report
28/10/2013 06:23
C1q deficiency is a rare disease that is associated with a high probability of developing systemic lupus erythematosus. We report a 4-year-old Japanese girl who presented with fever, facial erythema, joint pain, and oral ulceration. Complement defici
Meta-analysis confirms association between TNFA-G238A variant and JIA, and between PTPN22-C1858T variant and oligoarticular, RF-polyarticular and RF-positive polyarticular JIA
26/10/2013 03:50
Background: Although more than 100 non-HLA variants have been tested for associations with juvenile idiopathic arthritis (JIA) in candidate gene studies, only a few have been replicated. We sought to replicate reported associations of single nucleoti
Moroccan parents caring for children with juvenile idiopathic arthritis: positive and negative aspects of their experiences
20/10/2013 19:00
Background: Juvenile idiopathic arthritis (JIA) can lead to serious disability in children and adolescents, requiring intensive home care usually provided by parents .These parents must also cope with physical, familial, social and financial constrai
Elevated levels of CXCL10 in the Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) during and between febrile episodes; an indication of a persistent activation of the innate immune system
18/10/2013 01:10
Background: The Periodic Fever, Aphthous stomatitis, Pharyngitis and cervical Adenitis syndrome (PFAPA) is the most common periodic fever syndrome in childhood. Clinically, PFAPA may resemble autoinflammatory diseases, but the etiology is not fully u
Temporomandibular signs, symptoms, joint alterations and disease activity in juvenile idiopathic arthritis -- an observational study
17/10/2013 20:09
Background: Juvenile idiopathic arthritis (JIA) is a heterogeneous disease that frequently affects also the temporomandibular joint (TMJ) and associated structures. The main aim of this observational study was to describe systematically orofacial cli
Chorea, a little-known manifestation in systemic lupus erythematosus: short literature review and four case reports
17/10/2013 00:02
Chorea is a movement disorder that may be found in children due to several causes. Here we focus especially on Systemic Lupus Erythematosus associated chorea. First we outline its epidemiology, hypothesized pathogenesis, clinical presentation and tre
Malignancies in children and young adults on etanercept: summary of cases from clinical trials and post marketing reports
02/10/2013 06:30
Background: Malignancy risk may be increased in chronic inflammatory conditions that are mediated by tumor necrosis factor (TNF), such as juvenile idiopathic arthritis (JIA), but the role of TNF in human cancer biology is unclear. In response to a 20
Understanding treatment decision making in juvenile idiopathic arthritis: a qualitative assessment
01/10/2013 00:08
Background: The increase in therapeutic options for juvenile idiopathic arthritis (JIA) has added complexity to treatment decisions. Shared decision making has the potential to help providers and families work together to choose the best possible opt
Clinical patterns of juvenile idiopathic arthritis in Zambia
14/09/2013 10:56
Background: Juvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders with different disease manifestations among various populations. There are few reports of JIA among indigenous Africans especially sub-Saharan Africa. We present he
DC-SIGN gene promoter variants and IVIG treatment response in Kawasaki disease
06/09/2013 01:24
Background: Genetic variants in the inhibiting FcgammaRIIB mediate anti-inflammatory responses and influence IVIG refractoriness (IVIG-R). However, these variants are rare in Asian and Hispanic populations so other genes in the pathway could be poten
Evaluation of anti-citrullinated type II collagen and anti-citrullinated vimentin antibodies in patients with juvenile idiopathic arthritis
29/08/2013 22:06
Background: To determine the prevalence and significance of anti-citrullinated vimentin and anti-citrullinated type II collagen antibodies and elucidate their role in the disease process of juvenile idiopathic arthritis (JIA). Methods: Sera were obta
Exercise in children with joint hypermobility syndrome and knee pain: a randomised controlled trial comparing exercise into hypermobile versus neutral knee extension
14/08/2013 03:49
Background: Knee pain in children with Joint Hypermobility Syndrome (JHS) is traditionally managed with exercise, however the supporting evidence for this is scarce. No trial has previously examined whether exercising to neutral or into the hypermobi
Safety and immunogenicity of the quadrivalent HPV vaccine in female Systemic Lupus Erythematosus patients aged 12 to 26 years
07/08/2013 15:12
Background: Women with SLE have higher rates of persistent human papilloma virus (HPV) infections and precancerous lesions than healthy women. HPV vaccine is safe and effective in healthy females aged 9--26 years. There are limited data on the safety
Late development of coronary artery abnormalities could be associated with persistence of non-fever symptoms in Kawasaki disease
31/07/2013 19:48
Background: Persistent fever after intravenous immunoglobulin (IVIG) is considered to be a major criterion of IVIG resistance in Kawasaki disease (KD), and a risk factor for the development of coronary artery abnormalities (CAA). However, the importa
Adaptation of the methotrexate in rheumatoid arthritis knowledge questionnaire (MiRAK) for use with parents of children with juvenile idiopathic arthritis: a qualitative study
04/07/2013 00:35
Background: Although Methotrexate (MTX) is one of the most commonly prescribed disease-modifying drugs in JIA no questionnaire exists that assesses the knowledge of parents about this drug. A 60-item questionnaire was recently developed to measure rh
Employment of a needs assessment survey to shape a novel web-based pediatric rheumatology curriculum for primary care providers
06/06/2013 11:15
Background: Pediatric rheumatology faces many challenges due to the shortage of board certified physicians in the field and the imbalance in their geographic distribution. This shortage has required primary care physicians and adult rheumatologists t
Retinal vasculitis in two pediatric patients with systemic lupus erythematosus: a case report
05/06/2013 10:33
We report two pediatric female patients with systemic lupus erythematosus (SLE) who presented with decreased vision. Both patients were found to have retinal vasculitis and occlusive disease. The first patient also presented with vitreous hemorrhage
The financial burden of juvenile idiopathic arthritis: a Nova Scotia experience
29/05/2013 17:06
Background: Juvenile idiopathic arthritis (JIA) is the most common childhood rheumatic illness. There is little published data on the financial burden of this illness. The primary objective of this study was to determine the annual costs borne by fam
Mothers' reports of the difficulties that their children experience in taking methotrexate for Juvenile Idiopathic Arthritis and how these impact on quality of life
29/05/2013 04:45
Background: Children who take methotrexate for juvenile idiopathic arthritis may experience side effects, including nausea and vomiting, leading to anticipatory nausea in some children, and fear of injections or blood tests. The aim of this study was
A unique, interactive and web-based pediatric rheumatology teaching module: residents' perceptions
28/05/2013 03:39
Background: The limited availability of pediatric rheumatologists for teaching in pediatric residency programs negatively impacts resident education about rheumatology. At present, there are no educational websites available for trainees to learn abo
Pain experience in children with juvenile idiopathic arthritis treated with anti-TNF agents compared to non-biologic standard treatment
06/05/2013 10:54
Background: Anti-TNF agents have proven efficacy in children with severe juvenile idiopathic arthritis (JIA) who are unresponsive to standard therapy. Therefore pain reduction or elimination could be expected. The aim of this study was to compare the
Rheumatic symptoms in childhood leukaemia and lymphoma-a ten-year retrospective study
04/05/2013 11:03
Background: The initial symptoms of childhood leukaemia and lymphoma are often similar to those of juvenile idiopathic arthritis (JIA). In our study, we analyzed the frequency and characteristics of musculoskeletal complaints as the initial presentin
Limb girdle muscular dystrophy type 2B masquerading as inflammatory myopathy: case report
03/05/2013 23:12
Limb girdle muscular dystrophy type 2B is a rare subtype of muscular dystrophy, the predominant feature of which is muscle weakness. The disease is caused by an autosomal recessively inherited reduction/absence of muscle dysferlin due to a mutation i
Osteochondral lesions in children with juvenile idiopathic arthritis
01/05/2013 23:42
Background: Joint pain and swelling are typical symptoms in children with juvenile idiopathic arthritis (JIA) and these are often related to inflammation of the joint. Juvenile osteochondritis dissecans (JOCD), that is separation of a bone-cartilage
Maximal mouth opening capacity: percentiles for healthy children 4--17 years of age
23/04/2013 01:00
Background: A reduced mouth opening capacity may be one of the first clinical signs of pathological changes in the masticatory system. The aim of this retrospective cross-sectional study was to create age related percentiles for unassisted maximal mo
Superior efficacy of Adalimumab in treating childhood refractory chronic uveitis when used as first biologic modifier drug: Adalimumab as starting anti-TNF-alpha therapy in childhood chronic uveitis
15/04/2013 14:33
Background: Nonetheless biologic modifier therapies are available treatment strategies for sight-threatening uveitis in children, the lack of evidence from head-to-head randomized controlled studies limits our understanding of timing of therapy when
Reviewer Acknowledgement 2012
13/04/2013 03:39
Contributing reviewersThe Editors of Pediatric Rheumatology would like to thank all our reviewers who have contributed to the journal in Volume 10 (2012).
MRI guided wire localization muscle biopsy in a child with juvenile dermatomyositis
08/04/2013 17:57
A novel technique for preoperative MRI guided wire localization for targeted surgical excisional biopsy of muscle is described in a pediatric patient with juvenile dermatomyositis (JDM). This technique allows for preoperative localization of abnormal
Autoinflammatory gene polymorphisms and susceptibility to UK juvenile idiopathic arthritis
02/04/2013 17:12
Background: To investigate the autoinflammatory hereditary periodic fever syndrome genes MVK and TNFRSF1A, and the NLRP1 and IL1 genes, for association with juvenile idiopathic arthritis (JIA). Methods: For MVK, TNFRSF1A and NLRP1 pair-wise tagging S
Out-of-clinic patient communication in paediatric rheumatology: the extent and nature of demand
27/03/2013 09:42
Background: Traditional funding models for public paediatric rheumatology care are typically based on providing medical services for a defined number of clinics per week. Anecdotally there is significant demand by patients and families for out-of-cli
Idiopathic juvenile osteoporosis: a cross-sectional single-centre experience with bone histomorphometry and quantitative computed tomography
26/03/2013 11:45
Background: Idiopathic juvenile osteoporosis (IJO) is a rare condition of poorly understood etiology and pathophysiology that affects otherwise healthy children. This condition is characterized clinically by bone pain and vertebral fractures; spontan
Time to share
26/03/2013 11:45
In the following a brief commentary is given on a new European project that aims to provide the European countries with recommendations for the care of children and yound adults with rheumatic diseases. These recommendations will be based on surveys
Coronary artery involvement in pediatric Takayasu¿s arteritis: Case report and literature review
26/03/2013 11:45
Takayasu’s arteritis (TA) is a form of chronic vasculitis that typically occurs in young adult Asian females, but it can also present in younger patients not fitting this classic profile. In these cases, the sequelae are generally similar to those
Treatment preferences in juvenile idiopathic arthritis -- a comparative analysis in two health care systems
26/03/2013 11:45
Background: Variations in the treatment of juvenile idiopathic arthritis (JIA) may impact on quality of care. The objective of this study was to identify and compare treatment approaches for JIA in two health care systems. Methods: Paediatric rheumat
Notice of redundant publication: Aerobic capacity and disease activity in children, adolescents and young adults with juvenile idiopathic arthritis (JIA)
26/03/2013 11:45
The Editors-in-Chief would like to alert readers that due to an error during the publication process this article was published twice. The original article can be found in this journal [2].