Recent items - Current Diabetes Reports
The Genetics of Insulin Resistance: Where's Waldo?
08/09/2010 13:21
The Genetics of Insulin Resistance: Where's Waldo? Curr Diab Rep. 2010 Sep 7; Authors: Watanabe RM The physiologic hallmarks of type 2 diabetes are insulin resistance in hepatic and peripheral tissues and pancreatic beta-cell dysfunction. Thus, genetic loci underlying susceptibility to type 2 diabetes are likely to map to one of these endophenotypes. Genome-wide association studies have now identified up to 38 susceptibility loci for type 2 diabetes and a numb [...]
08/09/2010 13:21
The Genetics of Insulin Resistance: Where's Waldo? Curr Diab Rep. 2010 Sep 7; Authors: Watanabe RM The physiologic hallmarks of type 2 diabetes are insulin resistance in hepatic and peripheral tissues and pancreatic beta-cell dysfunction. Thus, genetic loci underlying susceptibility to type 2 diabetes are likely to map to one of these endophenotypes. Genome-wide association studies have now identified up to 38 susceptibility loci for type 2 diabetes and a numb [...]
Preconception Counseling for Adolescent Females with Type 1 Diabetes: The READY-Girls Program.
08/09/2010 13:21
Preconception Counseling for Adolescent Females with Type 1 Diabetes: The READY-Girls Program. Curr Diab Rep. 2010 Sep 7; Authors: Hood KK PMID: 20820956 [PubMed - as supplied by publisher]
08/09/2010 13:21
Preconception Counseling for Adolescent Females with Type 1 Diabetes: The READY-Girls Program. Curr Diab Rep. 2010 Sep 7; Authors: Hood KK PMID: 20820956 [PubMed - as supplied by publisher]
Getting (the Most) Out of the Research Business: Interventions for Youth with T1DM.
08/09/2010 13:21
Getting (the Most) Out of the Research Business: Interventions for Youth with T1DM. Curr Diab Rep. 2010 Sep 7; Authors: Harris MA, Freeman KA, Duke DC We review research on psychosocial interventions to improve outcomes for youth with type 1 diabetes mellitus. Specifically, we discuss individual- and small group-focused, family-focused, group-focused, and other interventions. After reviewing extant research in each area, we discuss how the current evidence bas [...]
08/09/2010 13:21
Getting (the Most) Out of the Research Business: Interventions for Youth with T1DM. Curr Diab Rep. 2010 Sep 7; Authors: Harris MA, Freeman KA, Duke DC We review research on psychosocial interventions to improve outcomes for youth with type 1 diabetes mellitus. Specifically, we discuss individual- and small group-focused, family-focused, group-focused, and other interventions. After reviewing extant research in each area, we discuss how the current evidence bas [...]
Loss and Preservation of beta-Cell Function: Two Treatment Regimes Targeting T or B Lymphocytes.
13/08/2010 12:07
Loss and Preservation of beta-Cell Function: Two Treatment Regimes Targeting T or B Lymphocytes. Curr Diab Rep. 2010 Aug 12; Authors: Ziegler AG, Walter M PMID: 20703833 [PubMed - as supplied by publisher]
13/08/2010 12:07
Loss and Preservation of beta-Cell Function: Two Treatment Regimes Targeting T or B Lymphocytes. Curr Diab Rep. 2010 Aug 12; Authors: Ziegler AG, Walter M PMID: 20703833 [PubMed - as supplied by publisher]
Virus Infections and Type 1 Diabetes Risk.
04/08/2010 13:51
Virus Infections and Type 1 Diabetes Risk. Curr Diab Rep. 2010 Aug 3; Authors: Roivainen M, Klingel K Common intestinal infections caused by human enteroviruses (HEVs) are considered major environmental factors predisposing to type 1 diabetes (T1D). In spite of the active research of the field, the HEV-induced pathogenetic processes are poorly understood. Recently, after the first documented report on HEV infections in the pancreatic islets of deceased T1D pat [...]
04/08/2010 13:51
Virus Infections and Type 1 Diabetes Risk. Curr Diab Rep. 2010 Aug 3; Authors: Roivainen M, Klingel K Common intestinal infections caused by human enteroviruses (HEVs) are considered major environmental factors predisposing to type 1 diabetes (T1D). In spite of the active research of the field, the HEV-induced pathogenetic processes are poorly understood. Recently, after the first documented report on HEV infections in the pancreatic islets of deceased T1D pat [...]
Pediatric Islet Autotransplantation: Indication, Technique, and Outcome.
04/08/2010 13:51
Pediatric Islet Autotransplantation: Indication, Technique, and Outcome. Curr Diab Rep. 2010 Aug 3; Authors: Bellin MD, Sutherland DE Chronic pancreatitis is a rare disease in childhood. However, when severe, a total pancreatectomy may be the only option to relieve pain and restore quality of life. An islet autotransplant performed at the time of pancreatectomy can prevent or minimize the postsurgical diabetes that would otherwise result from pancreatectomy al [...]
04/08/2010 13:51
Pediatric Islet Autotransplantation: Indication, Technique, and Outcome. Curr Diab Rep. 2010 Aug 3; Authors: Bellin MD, Sutherland DE Chronic pancreatitis is a rare disease in childhood. However, when severe, a total pancreatectomy may be the only option to relieve pain and restore quality of life. An islet autotransplant performed at the time of pancreatectomy can prevent or minimize the postsurgical diabetes that would otherwise result from pancreatectomy al [...]
Immune Intervention in Children with Type 1 Diabetes.
31/07/2010 05:07
Related Articles Immune Intervention in Children with Type 1 Diabetes. Curr Diab Rep. 2010 Jul 29; Authors: Ludvigsson J, Not only T cells but also B cells play a role in the autoimmune process. Both monoclonal antiCD3 and antiCD20 antibodies seem efficacious. However, such treatments need to be refined to minimize adverse events. Use of autoantigens to create tolerance is a concept with great potential. GAD65 treatment has shown efficacy without adverse eve [...]
31/07/2010 05:07
Related Articles Immune Intervention in Children with Type 1 Diabetes. Curr Diab Rep. 2010 Jul 29; Authors: Ludvigsson J, Not only T cells but also B cells play a role in the autoimmune process. Both monoclonal antiCD3 and antiCD20 antibodies seem efficacious. However, such treatments need to be refined to minimize adverse events. Use of autoantigens to create tolerance is a concept with great potential. GAD65 treatment has shown efficacy without adverse eve [...]
Islet Transplantation: Alternative Sites.
29/07/2010 14:56
Islet Transplantation: Alternative Sites. Curr Diab Rep. 2010 Jul 28; Authors: Rajab A The portal vein is currently the site of choice for clinical islet transplantation, even though it is far from being an ideal site. Low oxygen tension and the induction of an inflammatory response impair islet implantation and lead to significant early loss. Even if enough islets survive the early implantation period to render insulin independence, few patients maintain it. [...]
29/07/2010 14:56
Islet Transplantation: Alternative Sites. Curr Diab Rep. 2010 Jul 28; Authors: Rajab A The portal vein is currently the site of choice for clinical islet transplantation, even though it is far from being an ideal site. Low oxygen tension and the induction of an inflammatory response impair islet implantation and lead to significant early loss. Even if enough islets survive the early implantation period to render insulin independence, few patients maintain it. [...]
Virus Infections: Lessons from Pancreas Histology.
29/07/2010 14:56
Virus Infections: Lessons from Pancreas Histology. Curr Diab Rep. 2010 Jul 28; Authors: Dotta F, Galleri L, Sebastiani G, Vendrame F Type 1 diabetes mellitus is a chronic autoimmune disease resulting from the progressive immune-mediated destruction of pancreatic beta cells in genetically susceptible individuals, with the likely contribution of environmental factors, among which viruses have been extensively studied. The pathologic hallmark of the disease is in [...]
29/07/2010 14:56
Virus Infections: Lessons from Pancreas Histology. Curr Diab Rep. 2010 Jul 28; Authors: Dotta F, Galleri L, Sebastiani G, Vendrame F Type 1 diabetes mellitus is a chronic autoimmune disease resulting from the progressive immune-mediated destruction of pancreatic beta cells in genetically susceptible individuals, with the likely contribution of environmental factors, among which viruses have been extensively studied. The pathologic hallmark of the disease is in [...]
The Role of Kidney-Pancreas Transplantation in Diabetic Kidney Disease.
28/07/2010 13:03
The Role of Kidney-Pancreas Transplantation in Diabetic Kidney Disease. Curr Diab Rep. 2010 Jul 27; Authors: Wiseman AC For patients with type 1 diabetes, innovations in insulin formulations and delivery have improved the ability to achieve excellent blood glucose control. However, it is uncommon to achieve euglycemia, particularly while avoiding complications arising from hypoglycemia. Pancreas transplantation remains the only broadly applied treatment strate [...]
28/07/2010 13:03
The Role of Kidney-Pancreas Transplantation in Diabetic Kidney Disease. Curr Diab Rep. 2010 Jul 27; Authors: Wiseman AC For patients with type 1 diabetes, innovations in insulin formulations and delivery have improved the ability to achieve excellent blood glucose control. However, it is uncommon to achieve euglycemia, particularly while avoiding complications arising from hypoglycemia. Pancreas transplantation remains the only broadly applied treatment strate [...]