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Recent items - European Heart Journal

Cardiac involvement in myotonic dystrophy: a nationwide cohort study
21/08/2014 11:11
Aims To quantify the association between myotonic dystrophy (DM) and cardiac disease in a nationwide cohort. Methods and results We identified a nationwide cohort of 1146 DM patients (period 1977–2011) using the National Patient Registry (NPR
Improved diagnosis of idiopathic giant cell myocarditis and cardiac sarcoidosis by myocardial gene expression profiling
21/08/2014 11:11
Aims Improvement of clinical diagnostics of idiopathic giant cell myocarditis (IGCM) and cardiac sarcoidosis (CS), two frequently fatal human myocardial diseases. Currently, IGCM and CS are diagnosed based on differential patterns of inflammatory ce
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society
21/08/2014 11:11
Aims Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular
Titin gene mutations are common in families with both peripartum cardiomyopathy and dilated cardiomyopathy
21/08/2014 11:11
Aim Peripartum cardiomyopathy (PPCM) can be an initial manifestation of familial dilated cardiomyopathy (DCM). We aimed to identify mutations in families that could underlie their PPCM and DCM. Methods and results We collected 18 families with PPCM
Multiparametric assessment of myocarditis using simultaneous positron emission tomography/magnetic resonance imaging
21/08/2014 11:11
Clinical images of radiation-induced heart disease
21/08/2014 11:11
The Notch pathway controls fibrotic and regenerative repair in the adult heart
21/08/2014 11:11
Aims In the adult heart, Notch signalling regulates the response to injury. Notch inhibition leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac hypertrophy and fibrosis. The role of Notch in the mesenchymal stroma
Gene expression profiling: time to file diagnostic uncertainty in inflammatory heart diseases?
21/08/2014 11:11
The Notch pathway: a novel target for myocardial remodelling therapy?
21/08/2014 11:11
Pathological ventricle remodelling, which follows a cardiac insult, causes heart failure. Despite the existence of multiple pharmaceutical approaches, heart failure is one of the leading causes of death worldwide and there is an urgent need to explo
CardioPulse Articles * Pre-hospital care: a critical phase of the acute cardiovascular care management process * Intracardiac 'leadless' pacemakers are going in all over Europe! * PREvention of late Stent Thrombosis by an Interdisciplinary Global Eur
21/08/2014 11:11
Myotonic dystrophy: time for evidence-based therapy
21/08/2014 11:11
Ruptured aneurysm of non-coronary sinus of valsalva as a rare cause of chest pain
14/08/2014 14:54
Assessment of microRNAs in patients with unstable angina pectoris
14/08/2014 14:54
Aims While cardiac troponin measurements have significantly improved the early diagnosis of myocardial infarction, the timely biomarker-based diagnosis of unstable angina pectoris (UAP) remains a major unmet clinical challenge. The aim of this study
CardioPulse Articles * Global Heart Failure Awareness Programme of the Heart Failure Association * European Heart Failure Awareness Days * Global Heart Failure Awareness Programme in Athens * Highlights from late breaking trials at Heart Failure Cong
14/08/2014 14:54
Massive intracardiac thromboembolism following spinal surgery
14/08/2014 14:54
Higher plasma CXCL12 levels predict incident myocardial infarction and death in chronic kidney disease: findings from the Chronic Renal Insufficiency Cohort study
14/08/2014 14:54
Aims Genome-wide association studies revealed an association between a locus at 10q11, downstream from CXCL12, and myocardial infarction (MI). However, the relationship among plasma CXCL12, cardiovascular disease (CVD) risk factors, incident MI, and
Pre-specified vs. post-hoc subgroup analyses: are we wiser before or after a trial has been performed?
14/08/2014 14:54
Coronary stenosis and transmural perfusion across the left ventricular wall
14/08/2014 14:54
Aortic stenosis and coronary artery disease: What do we know? What don't we know? A comprehensive review of the literature with proposed treatment algorithms
14/08/2014 14:54
Aortic valve stenosis is the most common form of valvular heart disease in the elderly population and occurs frequently in conjunction with coronary artery disease. The standard treatment option for patients with these two conditions has been surgic
Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
14/08/2014 14:54
Aims The optimal platelet inhibition strategy for ACS patients managed without revascularization is unknown. We aimed to evaluate efficacy and safety of ticagrelor vs. clopidogrel in the non-ST-elevation acute coronary syndrome (NSTE-ACS) subgroup o
Ventricular septal rupture complicating acute myocardial infarction: a contemporary review
14/08/2014 14:54
Ventricular septal rupture (VSR) after acute myocardial infarction is increasingly rare in the percutaneous coronary intervention era but mortality remains high. Prompt diagnosis is key and definitive surgery, though challenging and associated with
Impact of anatomical and functional severity of coronary atherosclerotic plaques on the transmural perfusion gradient: a [15O]H2O PET study
14/08/2014 14:54
Background Myocardial ischaemia occurs principally in the subendocardial layer, whereas conventional myocardial perfusion imaging provides no information on the transmural myocardial blood flow (MBF) distribution. Subendocardial perfusion measuremen
Like a dented bumper: a heart impressed by a giant left atrial appendage in a 22-year-old patient
14/08/2014 14:54
A randomized, prospective, intercontinental evaluation of a bioresorbable polymer sirolimus-eluting coronary stent system: the CENTURY II (Clinical Evaluation of New Terumo Drug-Eluting Coronary Stent System in the Treatment of Patients with Coronary
08/08/2014 10:47
Aim The aim of this study was to establish safety and efficacy of a new sirolimus-eluting stent with bioresorbable polymer, Ultimaster (BP-SES). Sirolimus-eluting stent with bioresorbable polymer was compared with everolimus-eluting, permanent polym
Successful antegrade revascularization by the innovation of composite core dual coil in a three-vessel total occlusive disease for cardiac arrest patient using extracorporeal membrane oxygenation
08/08/2014 10:47
A novel clinical risk prediction model for sudden cardiac death in hypertrophic cardiomyopathy (HCM Risk-SCD)
08/08/2014 10:47
Aims Hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death (SCD) in young adults. Current risk algorithms provide only a crude estimate of risk and fail to account for the different effect size of individual risk factors. The
CardioPulse Articles * FastTrack: a key success factor for the European Heart Journal * Pre-hospital care: a critical phase of the acute cardiovascular care management process * Electromagnetic steering for catheter ablation procedures * Book Review
08/08/2014 10:47
The importance of patient-reported outcomes: a call for their comprehensive integration in cardiovascular clinical trials
08/08/2014 10:47
Patient-reported outcomes (PROs), such as symptoms, health-related quality of life (HRQOL), or patient perceived health status, are reported directly by the patient and are powerful tools to inform patients, clinicians, and policy-makers about morbi
Drug-eluting stent technology: progress beyond the polymer
08/08/2014 10:47
Combined intracardiac and epicardial device closure of a large left ventricular pseudoaneurysm
08/08/2014 10:47
Surgical myectomy improves pulmonary hypertension in obstructive hypertrophic cardiomyopathy
08/08/2014 10:47
Aims Characterization of pulmonary hypertension (PH) and the effects of myectomy in hypertrophic cardiomyopathy (HCM) remain poorly defined. The aim of the study was to investigate the effect of myectomy on PH in HCM. Methods and results This is a
Understanding IMPROVE-IT and the cardinal role of LDL-C lowering in CVD prevention
08/08/2014 10:47
Long-term survival after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: a comparison with general population
08/08/2014 10:47
Aims We decided to determine the long-term survival of patients after alcohol septal ablation (ASA) for hypertrophic obstructive cardiomyopathy (HOCM) and compare this with the general population. Methods and results A total of 178 highly symptomat
Simultaneous massive pulmonary embolism and acute myocardial infarction, associated with patent foramen ovale
08/08/2014 10:47
Lack of association between dual antiplatelet therapy use and stent thrombosis between 1 and 12 months following resolute zotarolimus-eluting stent implantation
01/08/2014 15:52
Aim The optimal duration of dual antiplatelet therapy (DAPT) following the use of new generation drug-eluting stents is unknown. Methods and results The association between DAPT interruption and the rates of stent thrombosis (ST) and cardiac death/
Papillary fibroelastoma of the mitral valve as an unusual cause of myocardial infarction in a 20-year-old patient
01/08/2014 15:52
Vascular signs of Takayasu's arteritis: porcelain aorta and the 'macaroni sign'
01/08/2014 15:52
Neoatherosclerosis as reason for stent failures beyond 5 years after drug-eluting stent implantation
01/08/2014 15:52
Mendelian randomization studies in coronary artery disease
01/08/2014 15:52
Epidemiological research over the last 50 years has discovered a plethora of biomarkers (including molecules, traits or other diseases) that associate with coronary artery disease (CAD) risk. Even the strongest association detected in such observati
Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction
01/08/2014 15:52
Aims Predicting the likely success of primary PCI to salvage potential infarcted myocardium is desirable. We compared early invasive parameters of coronary microcirculation function with the levels of circulating endothelin (ET-1) and 6-month ejecti
Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries
01/08/2014 15:52
Aims Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in pati
Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type
01/08/2014 15:52
Aim To investigate the putative modifying effect of dual antiplatelet therapy (DAPT) use on the incidence of stent thrombosis at 3 years in patients randomized to Endeavor zotarolimus-eluting stent (E-ZES) or Cypher sirolimus-eluting stent (C-SES).
Towards better clinical prediction models: seven steps for development and an ABCD for validation
01/08/2014 15:52
Clinical prediction models provide risk estimates for the presence of disease (diagnosis) or an event in the future course of disease (prognosis) for individual patients. Although publications that present and evaluate such models are becoming more
CardioPulse Articles * Pre-hospital care is critical for the entire acute cardiovascular care management process * The CABANA trial * Catheter Ablation vs. Antiarrhythmic Drug Therapy for Atrial Fibrillation trial information * British Cardiovascular
01/08/2014 15:52
Balancing ischaemia and bleeding with dual antiplatelet therapy: a resolute endeavour
01/08/2014 15:52
Peri-interventional management of novel oral anticoagulants in daily care: results from the prospective Dresden NOAC registry
21/07/2014 14:12
Aims Patients receiving novel oral anticoagulants (NOACs) frequently undergo interventional procedures. Short half-lives and rapid onset of action allow for short periods of NOAC interruption without heparin bridging. However, outcome data for this
Efficacy and safety of apixaban compared with aspirin in patients who previously tried but failed treatment with vitamin K antagonists: results from the AVERROES trial
21/07/2014 14:12
Aim The AVERROES double-blinded, randomized trial demonstrated that apixaban reduces the risk of stroke or systemic embolism (SSE) by 55% compared with aspirin without an increase in major bleeding in patients with atrial fibrillation either who pre
ECG pitfall: anterior myocardial infarction in dextrocardia
21/07/2014 14:12
Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial
21/07/2014 14:12
Aims The risk of stroke in patients with atrial fibrillation (AF) increases with age. In the ARISTOTLE trial, apixaban when compared with warfarin reduced the rate of stroke, death, and bleeding. We evaluated these outcomes in relation to patient ag
Hypertrophic cardiomyopathy and Anderson-Fabry disease: unravelling septal hypertrophy with T1-mapping CMR
21/07/2014 14:12
Cost-effectiveness of apixaban vs. current standard of care for stroke prevention in patients with atrial fibrillation
21/07/2014 14:12
Aims Warfarin, a vitamin K antagonist (VKA), has been the standard of care for stroke prevention in patients with atrial fibrillation (AF). Aspirin is recommended for low-risk patients and those unsuitable for warfarin. Apixaban is an oral anticoagu
Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial
21/07/2014 14:12
Aims There are no data regarding management and outcomes of major bleeding events in patients treated with oral factor Xa inhibitors. Methods and results Using data from ROCKET AF, we analysed the management and outcomes of major bleeding overall a
Initiation of warfarin in patients with atrial fibrillation: early effects on ischaemic strokes
21/07/2014 14:12
Aims An increased risk of stroke was observed in two atrial fibrillation (AF) trials of oral factor Xa inhibitors, when patients were transitioned to open label warfarin at the end of the study. The objective of this study is to determine whether in
An unusual cause of dyspnoea in a young man
21/07/2014 14:12