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Recent items - European Heart Journal

Lack of association between dual antiplatelet therapy use and stent thrombosis between 1 and 12 months following resolute zotarolimus-eluting stent implantation
01/08/2014 15:52
Aim The optimal duration of dual antiplatelet therapy (DAPT) following the use of new generation drug-eluting stents is unknown. Methods and results The association between DAPT interruption and the rates of stent thrombosis (ST) and cardiac death/
Papillary fibroelastoma of the mitral valve as an unusual cause of myocardial infarction in a 20-year-old patient
01/08/2014 15:52
Vascular signs of Takayasu's arteritis: porcelain aorta and the 'macaroni sign'
01/08/2014 15:52
Neoatherosclerosis as reason for stent failures beyond 5 years after drug-eluting stent implantation
01/08/2014 15:52
Mendelian randomization studies in coronary artery disease
01/08/2014 15:52
Epidemiological research over the last 50 years has discovered a plethora of biomarkers (including molecules, traits or other diseases) that associate with coronary artery disease (CAD) risk. Even the strongest association detected in such observati
Early change in invasive measures of microvascular function can predict myocardial recovery following PCI for ST-elevation myocardial infarction
01/08/2014 15:52
Aims Predicting the likely success of primary PCI to salvage potential infarcted myocardium is desirable. We compared early invasive parameters of coronary microcirculation function with the levels of circulating endothelin (ET-1) and 6-month ejecti
Reperfusion therapy for ST elevation acute myocardial infarction 2010/2011: current status in 37 ESC countries
01/08/2014 15:52
Aims Primary percutaneous coronary intervention (PPCI) is the preferred reperfusion therapy in ST-elevation myocardial infarction (STEMI). We conducted this study to evaluate the contemporary status on the use and type of reperfusion therapy in pati
Modifying effect of dual antiplatelet therapy on incidence of stent thrombosis according to implanted drug-eluting stent type
01/08/2014 15:52
Aim To investigate the putative modifying effect of dual antiplatelet therapy (DAPT) use on the incidence of stent thrombosis at 3 years in patients randomized to Endeavor zotarolimus-eluting stent (E-ZES) or Cypher sirolimus-eluting stent (C-SES).
Towards better clinical prediction models: seven steps for development and an ABCD for validation
01/08/2014 15:52
Clinical prediction models provide risk estimates for the presence of disease (diagnosis) or an event in the future course of disease (prognosis) for individual patients. Although publications that present and evaluate such models are becoming more
CardioPulse Articles * Pre-hospital care is critical for the entire acute cardiovascular care management process * The CABANA trial * Catheter Ablation vs. Antiarrhythmic Drug Therapy for Atrial Fibrillation trial information * British Cardiovascular
01/08/2014 15:52
Balancing ischaemia and bleeding with dual antiplatelet therapy: a resolute endeavour
01/08/2014 15:52
Edoxaban: a focused review of its clinical pharmacology
21/07/2014 14:12
Long-term anticoagulation treatment with warfarin has been associated with a number of limitations in clinical practice and there is a need for more convenient long-term anticoagulation treatment. One of the non-vitamin K oral anticoagulants in deve
Peri-interventional management of novel oral anticoagulants in daily care: results from the prospective Dresden NOAC registry
21/07/2014 14:12
Aims Patients receiving novel oral anticoagulants (NOACs) frequently undergo interventional procedures. Short half-lives and rapid onset of action allow for short periods of NOAC interruption without heparin bridging. However, outcome data for this
Direct oral anticoagulants in the treatment and long-term prevention of venous thrombo-embolism
21/07/2014 14:12
Direct oral anticoagulants (DOACs) specifically target factor IIa or Xa and represent a major step forward in the treatment of acute- and long-term prevention of venous thrombo-embolism (VTE). They are at least as effective and as safe as convention
Is there a period of liability with initiation of warfarin in patients with atrial fibrillation?
21/07/2014 14:12
Efficacy and safety of apixaban compared with aspirin in patients who previously tried but failed treatment with vitamin K antagonists: results from the AVERROES trial
21/07/2014 14:12
Aim The AVERROES double-blinded, randomized trial demonstrated that apixaban reduces the risk of stroke or systemic embolism (SSE) by 55% compared with aspirin without an increase in major bleeding in patients with atrial fibrillation either who pre
Heparin bridging in peri-procedural management of new oral anticoagulant: a bridge too far?
21/07/2014 14:12
ECG pitfall: anterior myocardial infarction in dextrocardia
21/07/2014 14:12
Efficacy and safety of apixaban compared with warfarin according to age for stroke prevention in atrial fibrillation: observations from the ARISTOTLE trial
21/07/2014 14:12
Aims The risk of stroke in patients with atrial fibrillation (AF) increases with age. In the ARISTOTLE trial, apixaban when compared with warfarin reduced the rate of stroke, death, and bleeding. We evaluated these outcomes in relation to patient ag
CardioPulse Articles * New oral anticoagulants for non-valvular atrial fibrillation: harder to handle than expected * Once-daily edoxaban: a safer option than well-managed warfarin for patients with atrial fibrillation? * The Quick Test: 80 years on
21/07/2014 14:12
Hypertrophic cardiomyopathy and Anderson-Fabry disease: unravelling septal hypertrophy with T1-mapping CMR
21/07/2014 14:12
Cost-effectiveness of apixaban vs. current standard of care for stroke prevention in patients with atrial fibrillation
21/07/2014 14:12
Aims Warfarin, a vitamin K antagonist (VKA), has been the standard of care for stroke prevention in patients with atrial fibrillation (AF). Aspirin is recommended for low-risk patients and those unsuitable for warfarin. Apixaban is an oral anticoagu
Management of major bleeding events in patients treated with rivaroxaban vs. warfarin: results from the ROCKET AF trial
21/07/2014 14:12
Aims There are no data regarding management and outcomes of major bleeding events in patients treated with oral factor Xa inhibitors. Methods and results Using data from ROCKET AF, we analysed the management and outcomes of major bleeding overall a
Initiation of warfarin in patients with atrial fibrillation: early effects on ischaemic strokes
21/07/2014 14:12
Aims An increased risk of stroke was observed in two atrial fibrillation (AF) trials of oral factor Xa inhibitors, when patients were transitioned to open label warfarin at the end of the study. The objective of this study is to determine whether in
An unusual cause of dyspnoea in a young man
21/07/2014 14:12
TAVI in a low left main coronary artery ostium and wide aortic sinus of Valsava
15/07/2014 21:41
The effect of cholesteryl ester transfer protein inhibition on lipids, lipoproteins, and markers of HDL function after an acute coronary syndrome: the dal-ACUTE randomized trial
15/07/2014 21:41
Aims The effects of cholesteryl ester transfer protein (CETP) inhibition on lipids, inflammation, and markers of high-density lipoprotein (HDL) function, following an acute coronary syndrome (ACS), are unknown. Methods and results The dal-ACUTE stu
The heart of the matter: a link between troponin and dementia?
15/07/2014 21:41
C-reactive protein and risk of cardiovascular and all-cause mortality in 268 803 East Asians
15/07/2014 21:41
Aims C-reactive protein concentrations are decreased in Asians compared with people of white European ethnicity. It is uncertain whether C-reactive protein is a robust biomarker of cardiovascular disease (CVD) in Asians. This study aimed to determin
ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD
15/07/2014 21:41
High-sensitivity cardiac troponin T and cognitive function and dementia risk: the atherosclerosis risk in communities study
15/07/2014 21:41
Aim Clinical cardiovascular disease is a major risk factor for cognitive impairment and dementia. However, less is known about the association of subclinical myocardial damage with cognition and dementia. We sought to examine the associations of hig
Left atrial dissection after mitral valve replacement
15/07/2014 21:41
Lipid lowering in patients with treatment-resistant hypertension: an analysis from the Treating to New Targets (TNT) trial
15/07/2014 21:41
Aim Patients with resistant hypertension are at high risk for adverse cardiovascular events. Efforts have been focused on lowering the surrogate endpoint of blood pressure (BP) with scant focus on reduction of hard cardiovascular endpoints. However,
High-sensitivity C-reactive protein: still need for next-generation biomarkers for remote future cardiovascular events
15/07/2014 21:41
Anti-inflammatory therapies for cardiovascular disease
15/07/2014 21:41
Atherothrombosis is no longer considered solely a disorder of lipoprotein accumulation in the arterial wall. Rather, the initiation and progression of atherosclerotic lesions is currently understood to have major inflammatory influences that encompa
CardioPulse Articles * A year of celebration at Mayo Clinic * The 'Young Acute Cardiovascular Care Association group' of the Acute Cardiovascular Care Association * Why are disease rates in Russia worse than the rest of Europe? * The Vascular Biology
15/07/2014 21:41
Very late bioresorbable scaffold thrombosis after discontinuation of dual antiplatelet therapy
15/07/2014 21:41
Renin-angiotensin system blockade: time for a reappraisal?
07/07/2014 10:49
Renin-angiotensin system antagonists and clinical outcomes in stable coronary artery disease without heart failure
07/07/2014 10:49
Aims The aim of this study was to determine whether angiotensin-converting enzyme inhibitor (ACEI) or angiotensin-II receptor blocker (ARB) use is associated with lower rates of cardiovascular events in patients with stable coronary artery disease (
Aortic dissection caused by intra-aortic balloon pumping
07/07/2014 10:49
Renal nerve ablation after SYMPLICITY HTN-3: confused at the higher level?
07/07/2014 10:49
Diagnosis of pheochromocytoma on physical examination
07/07/2014 10:49
Catheter-based renal denervation for treatment of patients with treatment-resistant hypertension: 36 month results from the SYMPLICITY HTN-2 randomized clinical trial
07/07/2014 10:49
Aim The aim of this study was to determine long-term results of renal artery denervation for treatment of treatment-resistant hypertension in the SYMPLICITY HTN-2 study. Methods SYMPLICITY HTN-2 randomized 106 subjects with treatment-resistant hype
Antihypertensive efficacy of angiotensin receptor blockers as monotherapy as evaluated by ambulatory blood pressure monitoring: a meta-analysis
07/07/2014 10:49
Aims Angiotensin receptor blockers (ARBs) are available in different dosages and it is common clinical practice to uptitrate if blood pressure goal is not achieved with the initial dose. Data on the incremental antihypertensive efficacy with uptitra
Importance of frailty in patients with cardiovascular disease
07/07/2014 10:49
Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality. With the ageing population, the prognostic determinants among others include frailty, health status, disability, and cognition. These constructs are seldom measured and
Central blood pressure: current evidence and clinical importance
07/07/2014 10:49
Pressure measured with a cuff and sphygmomanometer in the brachial artery is accepted as an important predictor of future cardiovascular risk. However, systolic pressure varies throughout the arterial tree, such that aortic (central) systolic pressu
Treating hypertension in the very elderly--benefits, risks, and future directions, a focus on the hypertension in the very elderly trial
07/07/2014 10:49
Although the number of individuals reaching 80 who are considered to be healthy is increasing, the very elderly are likely to have long-term conditions, to report symptoms and/or be taking at least one regular medication. The impact of antihypertens
Aliskiren alone or with other antihypertensives in the elderly with borderline and stage 1 hypertension: the APOLLO trial
07/07/2014 10:49
Aims We studied the unclear question whether blood pressure (BP) lowering reduces cardiovascular disease (CVD) in elderly individuals with systolic BP <160 mm Hg. Methods and results We initiated a randomized placebo-controlled stratified 2 x 2
CardioPulse Articles * What does the future hold for renal denervation? * Profile: Prof. Deepak L. Bhatt MD MPH FACC FAHA FESC * SYMPLICITY HTN-3 trial: what is it and what does it mean? * Was there real denervation in the SYMPLICITY HTN-3 trial? * W
07/07/2014 10:49
No post-conditioning in the human heart with thrombolysis in myocardial infarction flow 2-3 on admission
01/07/2014 13:24
Aims Proof-of-concept evidence suggests that mechanical ischaemic post-conditioning (PostC) reduces infarct size when applied immediately after culprit coronary artery re-opening in ST-elevation myocardial infarction (STEMI) patients with thrombolys
Worldwide experience with a totally subcutaneous implantable defibrillator: early results from the EFFORTLESS S-ICD Registry
01/07/2014 13:24
Aims The totally subcutaneous implantable-defibrillator (S-ICD) is a new alternative to the conventional transvenous ICD system to minimize intravascular lead complications. There are limited data describing the long-term performance of the S-ICD. T
The natural and unnatural history of the Mustard procedure: long-term outcome up to 40 years
01/07/2014 13:24
Aims To describe long-term survival, clinical outcome and ventricular systolic function in a longitudinally followed cohort of patients after Mustard repair for transposition of the great arteries (TGA). There is serious concern about the long-term
Echinococcosis of the heart
01/07/2014 13:24
Comparison of pathology of chronic total occlusion with and without coronary artery bypass graft
01/07/2014 13:24
Aims The aim of our study was to investigate chronic total occlusion (CTO) in human coronary arteries to clarify the difference between CTO with prior coronary artery bypass graft (CABG) and those without prior CABG. Methods and results A total of