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Recent items - The Daily Sign-Out

Novel cutaneous and pulmonary syndrome associated with mutations in STING
06/08/2014 14:35
Fascinating article describing a vasculopathic cutaneous and pulmonary syndrome associated with autosomal dominant mutations in TMEM173, the gene encoding stimulator of interferon genes (STING). An incredible body of work presented with num [...]
Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema
21/07/2014 06:49
Interesting abstract from American Journal of Pathology showing evidence for involvement of neutrophils serine proteinases in pathogenesis of emphysema. Abstract Cigarette smoking is a major factor for the development of pulmonary emphysema [...]
The Role of Vascular Endothelial Growth Factor in Pulmonary Arterial Hypertension: The Angiogenesis Paradox
21/07/2014 06:49
Current review focusing on the enigmatic role of VEGF in the pathogenesis of pulmonary arterial hypertension from American Journal of Respiratory Cell and Molecular Biology published online last month. Abstract Pulmonary arterial hypertensi [...]
CFTR: cystic fibrosis and beyond
21/07/2014 06:49
Excellent recent review of the role of the cystic fibrosis transmembrane conductance regulator in cystic fibrosis. Download WebPage.pdf
Multifocal Micronodular Pneumocyte Hyperplasia Mimicking Miliary TB
28/06/2014 20:26
Saturday morning interesting case report! Download Multifocal pneumocyte hyperplasia mimicking miliary TB case report Lee 2014
SNAI1 functional variant associated with decreased risk for lung cancer
27/06/2014 05:02
This is an abstract from the January 15, 2014 issue of American Journal of Respiratory and Critical Care Medicino that I just re-discovered this week and relates to one of my ongoing (and unrequited) obsession with epithelial-mesenchymal tr [...]
Web-based Tool for Assessing Transfusion Reactions
26/06/2014 19:09
The Hemovigilance Module of the CDC's National Healthcare Safety Network has an open access Web application for assessing transfusion reactions that is available at This tool is based on the NHSN Hemovigilance Module Surveill [...]
NHLBI Workshop Report: Matrix Biology in Idiopathic Pulmonary Fibrosis
25/06/2014 23:25
The June 2014 issue of American Journal of Pathology has this state-of-the-art review, based on a recent NHBLI workshop, of the various attributes of the lung extracellular matrix and its role in normal lung and in the development of IPF... [...]
Major Driver Mutations in Adenosquamous Lung Carcinomas
23/06/2014 22:51
The June 2014 issue of Journal of Thoracic Oncology (abstract) features a thorough study of major known driver mutations (EGFR, KRAS, ERBB2, BRAF, PIK3CA, AKT1, RET, and ALK) in a series of 76 patients from Fudan University Shanghai Cancer [...]
Ancient account of physician subspecialization
21/06/2014 22:19
This is a follow-up to my recent post on Herodotus describing 6th-century BC Babylonians relying on "social networking" for health care. In Book 2 of The Histories, Herodotus comments on Egyptian medicine (ca. 500 BC). In opposition to Baby [...]
Extratumoral lymphatic permeation as prognostic marker in NSCLC
20/06/2014 16:33
Matsumura and colleagues from the National Cancer Center Hospital East in Chiba, Japan recently reported in the Journal of Thoracic Oncology (abstract) their study of the location of lymphatic permeation in relation to the tumor and the eff [...]
Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma
19/06/2014 10:41
Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma Sent from – the personalized reading app for physicians on the iPad and iPhone Available in the Ap [...]
Blogging: Is it good or bad for journal article readership?
19/06/2014 00:44
Thoughtful post regarding the relationship between blogging about academic articles and actual reading of the same. When I blog about an article it is usually to call attention to an interesting, important, and provocative article that the [...]
Early adopters of using social networking in health care
11/06/2014 19:47
I decided to tackle The Histories by Herodotus this summer, after having enjoyed reading Thucydides' The Peloponnesian War last summer, and came across a fascinating description of Babylonian medicine by Herodotus in Book 1 that I connected [...]
Whole genome sequencing not ready for prime time
12/03/2014 20:55
Brief reaction from The Incidental Economist on recent JAMA article: Whole genome sequencing not ready for prime time. I agree that WGS is not ready for prime-time yet. Routine molecular testing--even for colon and lung in which there are m [...]
Mutations in Lung Adenosquamous Carcinomas
31/01/2014 18:42
Journal of Thoracic Oncology just issued a published ahead-of-print article that examined mutations of most frequent driver mutations seen in pulmonary adenocarcinomas in a series of 76 resected adenosquamous carcinomas of the lung. This is [...]
Future Directions in Idiopathic Pulmonary Fibrosis Research: NHBLI Conference Summary
17/01/2014 17:17
Results of an NHBLI workshop from November, 2012 published in current American Journal of Respiratory and Critical Care Medicine (2014; Vol. 189, No. 2). Definitely worth reading the entire article, if you have any interest in ILDs. Abstrac [...]
Update in TB and Non-TB Mycobacterial Disease
15/01/2014 17:19
Dick Menzies and Payam Nahid "Update in Tuberculosis and Nontuberculous Mycobacterial Disease 2012", American Journal of Respiratory and Critical Care Medicine, Vol. 188, No. 8 (2013), pp. 923-927. doi: 10.1164/rccm.201304-0687UP Update in [...]
5 Challenges Facing Health Systems
14/01/2014 19:57
Mary Mosquera, writing in Healthcare Finance News, outlines five broad challenges facing healthcare systems: Among the biggest challenges that healthcare executives are confronted with this year are: 1. Pacing the shift to value-based model [...]
Primary Ciliary Dyskinesia: Update and Review
25/11/2013 17:58
A very thorough and up-to-date review of primary ciliary dyskinesia, which is a heterogenous group of related disorders. Most of us learned about the diagnostic ultrastructural abnormalities described in these patients, but one point of int [...]
Chronic Bronchitis and Chronic Obstructive Lung Disease Review
18/11/2013 15:49
Although commonly thought of synonymous, or, at least, forming a spectrum, chronic bronchitis is distinct from COPD. This review focuses on the pathophysiology of chronic bronchitis and goblet cell hyperplasia and the association between sm [...]
RBC immunization in sickle cell disease--revisited
16/11/2013 18:44
Stella Chou and co-authors published a very interesting and somewhat disquieting paper in the August 8, 2013 edition of Blood (abstract), "High prevalence of RBC immunization in sickle cell disease despite transfusion from Rh-matched minori [...]
Does anemia impact hospital readmission rates after CABG surgery?
09/11/2013 23:48
Nadine Shehata and colleagues studied this question in a recently published article (abstract) in the August 2013 issue of Transfusion. This is a single-institution study of 2,102 patients who underwent CABG surgery at the University of Ott [...]
AHA White Paper on Utilization of Medical Resources
07/11/2013 21:22
The AHA has published a free white paper, "Appropriate Use of Medical Resources," that can be accessed and downloaded as a pdf file from the link. Of interest to pathologists, and particularly to laboratory medical directors and transfusion [...]
New government regs threaten medical testing labs - The Hill's Congress Blog
01/10/2013 06:51
Interesting (and frustrating) post from The Hill. Why are hospital and small independent labs being punished because of the actions of large commercial labs abusing the Medicare system? We are the ones trying to honestly provide a service t [...]
Role of Bone Marrow-Derived HPCs in Pulmonary Fibrosis
09/09/2013 20:23
Interesting article from AJRCCM just published online that adds to accumulating data implicating circulating bone marrow-derived hematopoietic progenitor cells in the development of lung fibrosis. Abstract below. Rationale: Bone marrow (BM) [...]
ETS2 mediates tumor suppressor function and MET inhibition in lung adenocarcinoma
13/05/2013 19:16
There was a very intriguing paper published online by Clinical Cancer Research on May 9 last week that should be of interest for those involved in lung cancer research. The authors are Mohamed Kabbout, Melinda Garcia, Junya Fujimoto, et al....
NKX2-1/TTF-1 drives pulmonary-specific differentiation in lung adenocarcinoma
08/05/2013 22:08
Snyder et al. recently published an intriguing report in Molecular Cell (21 March 2013) (featured free article) in which they convincingly demonstrate how tumors in which Nkx2-1 was deleted show striking different morphology from those in which Nkx2-
CAP releases guidelines for validating whole slide imaging
02/05/2013 06:03
The College of American Pathologists has released guidelines for validating whole slide imaging. While stating the lack of FDA approval for using WSI for primary diagnosis, the College is acknowledging the very likely adoption of WSI for primary diag
BRAF mutations in colorectal cancer: mini-review
26/04/2013 13:58
There has been a recent flurry of papers and reports from ASCO-GI 2013 pushing more molecular testing in colorectal cancer (CRC) and its clinical significance with regard to prognostic and predictive factors, especially with MMR/MSI. One area that ca
The Daily Sign-Out
26/03/2013 13:20
Surgical pathology and laboratory medicine for pathologists, oncologists, surgeons and patients.
Atomic force microscopy! EMT and idiopathic pulmonary fibrosis
23/03/2013 15:48
Here is a very intesting article I recently found with some very cool technology: Abstract: Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition
Imaging tumors in the future
29/01/2013 20:37
Baohong Yuan and Joshua Rychak have written an interesting review in the February 2013 American Journal of Pathology that outlines emerging techniques based on ultrasound to obtain functional and molecular imaging of tumors. Apart from being fascinat
Pathologists to Blame for Hindering Acquisition of Cancer Tissue for Genomic Testing?
07/01/2013 17:26
Medscape recently posted an article that discusses the need for standards for acquiring, preserving and storing cancer tissue, citing a recent Viewpoint article in JAMA by Drs. Laura Goetz, Kelly Bethel, and Eric Topol. If you have the chance, I...
New Device to Check Margins in Breast Cancer Surgery
05/01/2013 15:53
Just a follow-up to yesterday's post regarding surgical margins in breast cancer. Will this device obviate inking the specimen or the debate about how much margin is "enough"? Quoted from Medscape article by Zosia Chustecka: The new device, MarginPro
Controversy: Surgical Margins in Breast Cancer
04/01/2013 15:00
What is a clear margin in breast-conserving cancer surgery? ASCO Connection (link) hosts a point-counterpoint discussion by two contributors regarding surgical margins in breast cancer that would be of general interest to surgical pathologists. It is
Video: Dr. Jack West discusses changing views on molecular testing in NSCLC
03/01/2013 21:10
The Lungevity blog features a video of Dr. Jack West from Swedish Cancer Institute in Seattle discussing his evolving views regarding molecular testing for actionable driver mutations in non-small-cell lung cancer (NSCLC). Dr. West is a thought-leade