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Recent items - The Daily Sign-Out

Whole genome sequencing not ready for prime time
12/03/2014 20:55
Brief reaction from The Incidental Economist on recent JAMA article: Whole genome sequencing not ready for prime time. I agree that WGS is not ready for prime-time yet. Routine molecular testing--even for colon and lung in which there are m [...]
Mutations in Lung Adenosquamous Carcinomas
31/01/2014 18:42
Journal of Thoracic Oncology just issued a published ahead-of-print article that examined mutations of most frequent driver mutations seen in pulmonary adenocarcinomas in a series of 76 resected adenosquamous carcinomas of the lung. This is [...]
Future Directions in Idiopathic Pulmonary Fibrosis Research: NHBLI Conference Summary
17/01/2014 17:17
Results of an NHBLI workshop from November, 2012 published in current American Journal of Respiratory and Critical Care Medicine (2014; Vol. 189, No. 2). Definitely worth reading the entire article, if you have any interest in ILDs. Abstrac [...]
Update in TB and Non-TB Mycobacterial Disease
15/01/2014 17:19
Dick Menzies and Payam Nahid "Update in Tuberculosis and Nontuberculous Mycobacterial Disease 2012", American Journal of Respiratory and Critical Care Medicine, Vol. 188, No. 8 (2013), pp. 923-927. doi: 10.1164/rccm.201304-0687UP Update in [...]
5 Challenges Facing Health Systems
14/01/2014 19:57
Mary Mosquera, writing in Healthcare Finance News, outlines five broad challenges facing healthcare systems: Among the biggest challenges that healthcare executives are confronted with this year are: 1. Pacing the shift to value-based model [...]
Primary Ciliary Dyskinesia: Update and Review
25/11/2013 17:58
A very thorough and up-to-date review of primary ciliary dyskinesia, which is a heterogenous group of related disorders. Most of us learned about the diagnostic ultrastructural abnormalities described in these patients, but one point of int [...]
Chronic Bronchitis and Chronic Obstructive Lung Disease Review
18/11/2013 15:49
Although commonly thought of synonymous, or, at least, forming a spectrum, chronic bronchitis is distinct from COPD. This review focuses on the pathophysiology of chronic bronchitis and goblet cell hyperplasia and the association between sm [...]
RBC immunization in sickle cell disease--revisited
16/11/2013 18:44
Stella Chou and co-authors published a very interesting and somewhat disquieting paper in the August 8, 2013 edition of Blood (abstract), "High prevalence of RBC immunization in sickle cell disease despite transfusion from Rh-matched minori [...]
Does anemia impact hospital readmission rates after CABG surgery?
09/11/2013 23:48
Nadine Shehata and colleagues studied this question in a recently published article (abstract) in the August 2013 issue of Transfusion. This is a single-institution study of 2,102 patients who underwent CABG surgery at the University of Ott [...]
AHA White Paper on Utilization of Medical Resources
07/11/2013 21:22
The AHA has published a free white paper, "Appropriate Use of Medical Resources," that can be accessed and downloaded as a pdf file from the link. Of interest to pathologists, and particularly to laboratory medical directors and transfusion [...]
New government regs threaten medical testing labs - The Hill's Congress Blog
01/10/2013 06:51
Interesting (and frustrating) post from The Hill. Why are hospital and small independent labs being punished because of the actions of large commercial labs abusing the Medicare system? We are the ones trying to honestly provide a service t [...]
Role of Bone Marrow-Derived HPCs in Pulmonary Fibrosis
09/09/2013 20:23
Interesting article from AJRCCM just published online that adds to accumulating data implicating circulating bone marrow-derived hematopoietic progenitor cells in the development of lung fibrosis. Abstract below. Rationale: Bone marrow (BM) [...]
ETS2 mediates tumor suppressor function and MET inhibition in lung adenocarcinoma
13/05/2013 19:16
There was a very intriguing paper published online by Clinical Cancer Research on May 9 last week that should be of interest for those involved in lung cancer research. The authors are Mohamed Kabbout, Melinda Garcia, Junya Fujimoto, et al....
NKX2-1/TTF-1 drives pulmonary-specific differentiation in lung adenocarcinoma
08/05/2013 22:08
Snyder et al. recently published an intriguing report in Molecular Cell (21 March 2013) (featured free article) in which they convincingly demonstrate how tumors in which Nkx2-1 was deleted show striking different morphology from those in which Nkx2-
CAP releases guidelines for validating whole slide imaging
02/05/2013 06:03
The College of American Pathologists has released guidelines for validating whole slide imaging. While stating the lack of FDA approval for using WSI for primary diagnosis, the College is acknowledging the very likely adoption of WSI for primary diag
BRAF mutations in colorectal cancer: mini-review
26/04/2013 13:58
There has been a recent flurry of papers and reports from ASCO-GI 2013 pushing more molecular testing in colorectal cancer (CRC) and its clinical significance with regard to prognostic and predictive factors, especially with MMR/MSI. One area that ca
The Daily Sign-Out
26/03/2013 13:20
Surgical pathology and laboratory medicine for pathologists, oncologists, surgeons and patients.
Atomic force microscopy! EMT and idiopathic pulmonary fibrosis
23/03/2013 15:48
Here is a very intesting article I recently found with some very cool technology: Abstract: Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition
Imaging tumors in the future
29/01/2013 20:37
Baohong Yuan and Joshua Rychak have written an interesting review in the February 2013 American Journal of Pathology that outlines emerging techniques based on ultrasound to obtain functional and molecular imaging of tumors. Apart from being fascinat
Pathologists to Blame for Hindering Acquisition of Cancer Tissue for Genomic Testing?
07/01/2013 17:26
Medscape recently posted an article that discusses the need for standards for acquiring, preserving and storing cancer tissue, citing a recent Viewpoint article in JAMA by Drs. Laura Goetz, Kelly Bethel, and Eric Topol. If you have the chance, I...
New Device to Check Margins in Breast Cancer Surgery
05/01/2013 15:53
Just a follow-up to yesterday's post regarding surgical margins in breast cancer. Will this device obviate inking the specimen or the debate about how much margin is "enough"? Quoted from Medscape article by Zosia Chustecka: The new device, MarginPro
Controversy: Surgical Margins in Breast Cancer
04/01/2013 15:00
What is a clear margin in breast-conserving cancer surgery? ASCO Connection (link) hosts a point-counterpoint discussion by two contributors regarding surgical margins in breast cancer that would be of general interest to surgical pathologists. It is
Video: Dr. Jack West discusses changing views on molecular testing in NSCLC
03/01/2013 21:10
The Lungevity blog features a video of Dr. Jack West from Swedish Cancer Institute in Seattle discussing his evolving views regarding molecular testing for actionable driver mutations in non-small-cell lung cancer (NSCLC). Dr. West is a thought-leade