Recent items - British Journal of Pharmacology
Cyclosporin and tacrolimus impair insulin secretion and transcriptional regulation in INS‐1E beta‐cells
02/09/2010 14:06
02/09/2010 14:06
Methylglyoxal scavengers attenuate endothelial dysfunction induced by methylglyoxal and high concentrations of glucose
02/09/2010 14:06
02/09/2010 14:06
Cilostazol prevents amyloid β peptide25‐35‐induced memory impairment and oxidative stress in mice
02/09/2010 14:06
02/09/2010 14:06
Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via several receptor pathways
02/09/2010 14:06
02/09/2010 14:06
cAMP inhibits modulation of airway smooth muscle phenotype via the exchange protein activated by cAMP (Epac) and protein kinase A
26/08/2010 16:01
26/08/2010 16:01
Analysis of the actions of the novel dopamine receptor‐directed compounds, (S)‐OSU6162 and ACR16 at the D2 dopamine receptor
26/08/2010 16:01
26/08/2010 16:01
Pharmacokinetic analysis of pralidoxime after its intramuscular injection alone or in combination with atropine‐avizafone in healthy volunteers
26/08/2010 16:01
26/08/2010 16:01
RESEARCH PAPER: 2‐Methoxystypandrone represses RANKL‐mediated osteoclastogenesis by down‐regulating formation of TRAF6–TAK1 signalling complexes
23/08/2010 16:03
BACKGROUND AND PURPOSE 2‐Methoxystypandrone (2‐MS) is a naphthoquinone isolated from Polygonum cuspidatum, a Chinese herb used to treat bone diseases. Here we have determined whether 2‐MS antagonised osteoclast development and bone resorption.EXPERIMENTAL APPROACH RAW264.7 cells were treated with receptor activator of nuclear factor κB (NF‐κB) ligand (RANKL) to induce differentiation into osteoclasts. RT‐PCR and Western blot were used to analyse osteoclast‐associated gene expression and signalli [...]
23/08/2010 16:03
BACKGROUND AND PURPOSE 2‐Methoxystypandrone (2‐MS) is a naphthoquinone isolated from Polygonum cuspidatum, a Chinese herb used to treat bone diseases. Here we have determined whether 2‐MS antagonised osteoclast development and bone resorption.EXPERIMENTAL APPROACH RAW264.7 cells were treated with receptor activator of nuclear factor κB (NF‐κB) ligand (RANKL) to induce differentiation into osteoclasts. RT‐PCR and Western blot were used to analyse osteoclast‐associated gene expression and signalli [...]
RESEARCH PAPER: Insulin resistance in penile arteries from a rat model of metabolic syndrome
23/08/2010 16:03
BACKGROUND AND PURPOSE Metabolic and cardiovascular abnormalities accompanying metabolic syndrome, such as obesity, insulin resistance and hypertension, are all associated with endothelial dysfunction and are independent risk factors for erectile dysfunction. The purpose of the present study was to investigate the vascular effects of insulin in penile arteries and whether these effects are impaired in a rat model of insulin resistance and metabolic syndrome.EXPERIMENTAL APPROACH Penile arteries [...]
23/08/2010 16:03
BACKGROUND AND PURPOSE Metabolic and cardiovascular abnormalities accompanying metabolic syndrome, such as obesity, insulin resistance and hypertension, are all associated with endothelial dysfunction and are independent risk factors for erectile dysfunction. The purpose of the present study was to investigate the vascular effects of insulin in penile arteries and whether these effects are impaired in a rat model of insulin resistance and metabolic syndrome.EXPERIMENTAL APPROACH Penile arteries [...]
Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to Gs and Gi
23/08/2010 16:03
23/08/2010 16:03
DYSREGULATION OF EPITHELIAL NA+ ABSORPTION INDUCED BY INHIBITION OF THE KINASES TORC1 AND TORC2
23/08/2010 16:03
23/08/2010 16:03
Adenosine and inosine release during hypoxia in the isolated spinal cord of neonatal rats
23/08/2010 16:03
23/08/2010 16:03
Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland
23/08/2010 16:03
23/08/2010 16:03
Caffeine inhibits the viability and osteogenic differentiation of rat bone marrow‐derived mesenchymal stromal cells
19/08/2010 20:36
19/08/2010 20:36
Commentary: Tuning in to the “right” calcium channel regulation in experimental models of diabetes
19/08/2010 20:36
19/08/2010 20:36
Human atrial β1L‐adrenoceptor but not β3‐adrenoceptor activation increases force and Ca2+ current at physiological temperature
19/08/2010 20:36
19/08/2010 20:36
Pioglitazone attenuates prostatic enlargement in diet‐induced insulin‐resistant rats by altering lipid distribution and hyperinsulinemia
19/08/2010 20:36
19/08/2010 20:36
Emodin suppresses lipopolysaccharide‐induced pro‐inflammatory responses and NF‐κB activation by disrupting lipid rafts in CD14‐negative endothelial cells
19/08/2010 20:36
19/08/2010 20:36
Ibuprofen is a non‐competitive inhibitor of the peptide transporter hPEPT1 (SLC15A1): possible interactions between hPEPT1 substrates and ibuprofen
19/08/2010 20:36
19/08/2010 20:36
RESEARCH PAPER: Emodin, a natural product, selectively inhibits 11β‐hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet‐induced obese mice
18/08/2010 11:27
BACKGROUND AND PURPOSE 11β‐Hydroxysteroid dehydrogenase type 1 (11β‐HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome. Emodin, a natural product and active ingredient of various Chinese herbs, has been demonstrated to possess multiple biological activities. Here, we investigated the effects of emodin on 11β‐HSD1 and its ability to ameliorate metabolic disorders in diet‐induced obese (DIO) mice.EXPERIMENTAL APPROACH Scintillation proximity assay was performed to [...]
18/08/2010 11:27
BACKGROUND AND PURPOSE 11β‐Hydroxysteroid dehydrogenase type 1 (11β‐HSD1) is an attractive therapeutic target of type 2 diabetes and metabolic syndrome. Emodin, a natural product and active ingredient of various Chinese herbs, has been demonstrated to possess multiple biological activities. Here, we investigated the effects of emodin on 11β‐HSD1 and its ability to ameliorate metabolic disorders in diet‐induced obese (DIO) mice.EXPERIMENTAL APPROACH Scintillation proximity assay was performed to [...]
Activation of a nuclear factor of activated T‐lymphocyte‐3 (NFAT3) by oxidative stress in carboplatin‐mediated renal apoptosis
13/08/2010 15:16
13/08/2010 15:16
Pharmacogenetics of the mycophenolic acid targets inosine monophosphate dehydrogenases IMPDH1 and IMPDH2: gene sequence variation and functional genomics
12/08/2010 21:56
12/08/2010 21:56
Ciprofloxacin inhibits advanced glycation end products‐induced adhesion molecule expression on human monocytes
08/08/2010 21:39
08/08/2010 21:39
Regional enhancement of cannabinoid CB1 receptor desensitization in female adolescent rats following repeated Δ9‐tetrahydrocannabinol exposure
08/08/2010 21:39
08/08/2010 21:39
Possible involvement of the GLP‐1(9‐36) in the regional haemodynamic effects of GLP‐1(7‐36) in conscious rats
08/08/2010 21:39
08/08/2010 21:39
Selective inhibition of persistent sodium current by F 15845 prevents ischaemia‐induced arrhythmias
08/08/2010 21:39
08/08/2010 21:39
Angiotensin receptor type 1 antagonists protect against neuronal injury induced by oxygen‐glucose depletion
08/08/2010 21:39
08/08/2010 21:39
Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of α7 nicotinic receptors and internalization of NMDA receptors
08/08/2010 21:39
08/08/2010 21:39
Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro
08/08/2010 21:39
08/08/2010 21:39
Elusive equilibrium: the challenge of interpreting receptor pharmacology using calcium assays
08/08/2010 21:39
08/08/2010 21:39
Cis‐isomerism and other chemical requirements of steroidal agonists and partial agonists acting at TRPM3 channels
08/08/2010 21:39
08/08/2010 21:39
The proton‐coupled amino acid transporter, SLC36A1 (hPAT1), transports Gly‐Gly, Gly‐Sar and other Gly‐Gly mimetics
08/08/2010 21:39
08/08/2010 21:39
Inverse agonism of cannabinoid CB1 receptors potentiates LiCl‐induced nausea in the conditioned gaping model in rats
08/08/2010 21:39
08/08/2010 21:39
Reduced signal transduction by 5‐HT4 receptors after long‐term venlafaxine treatment in rats
08/08/2010 21:39
08/08/2010 21:39
Intersegmental vessel formation in zebrafish: requirement for VEGF but not BMP signalling revealed by selective and non‐selective BMP antagonists
08/08/2010 21:39
08/08/2010 21:39
GSK1562590, a slowly dissociating urotensin‐II receptor antagonist, exhibits prolonged pharmacodynamic activity ex vivo
08/08/2010 21:39
08/08/2010 21:39
Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; Advantages and pitfalls of differing methodologies
08/08/2010 21:39
08/08/2010 21:39
Sustained morphine‐mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf‐1‐ selective siRNA
08/08/2010 21:39
08/08/2010 21:39
Differential regulation of β2‐adrenoceptor‐mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non‐failing rat cardiac ventricle
08/08/2010 21:39
08/08/2010 21:39
The Abuse of Diuretics as Performance‐Enhancing Drugs and Masking Agents in Sport Doping: Pharmacology, Toxicology and Analysis
08/08/2010 21:39
08/08/2010 21:39
Histamine H1 receptor antagonist cetirizine impairs working memory processing speed, but not episodic memory
08/08/2010 21:39
08/08/2010 21:39
Quercetin potentiates insulin secretion and protects INS‐1 pancreatic β‐cells against oxidative damage via the ERK1/2 pathway
08/08/2010 21:39
08/08/2010 21:39
Effects of nominally selective inhibitors of the kinases P13K, SGK1 and PKB on the insulin‐dependent control of epithelial Na+ absorption
08/08/2010 21:39
08/08/2010 21:39